Low Flow Anaesthesia, is There a Difference Between 2 Modern Anaesthetic Machines Using Different Gas Reservoir

Not Applicable

Terminated

• Conditions: General Anaesthesia
• Interventions: Device: Flow-I, a modern anaesthetic machine without a bag/below/gas reservoir for compression of insufflation gas; Device: Asys, a anaesthetic machine with a bag/bellow for compression of gas to be insufflated

• Registration Number: NCT02013869
• Lead Sponsor: Jan Jakobsson

Brief Summary

To study the Flow-I breathing circle during low flow general anaesthesia, whether this non-below system has advantages reduced time to reach Et 1MAC (minimal alveolar concentration) and lower consumption of inhaled agent

Detailed Description

Assessing whether there are clinical differences in anaesthetic performance between standard anaesthesia workstation including a below and the new Flow-I device without a below

Study Timeline

• Study First Submitted: 2013-11-29
• Study First Submitted QC: 2013-12-11
• Study First Posted: 2013-12-17
• Study Start: 2015-05
• Primary Completion: 2017-08
• Study Completion: 2017-08
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-16
• Last Update Posted: 2024-03-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

ASA 1-2 patient 18 - 65 years scheduled for elective surgery

Exclusion Criteria

ASA > 2 heart failure COPD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Flow-I	Flow-I, a modern anaesthetic machine without a bag/below/gas reservoir for compression of insufflation gas	Wash in of desflurane (SupraneR) in an anaesthesia machine without below, a new technique that do not have abag/reservoir that is compressed but pushes the gas into the patient. This technique uses far less of fresh gas volume. Thus lower anaesthetic gas will be consumed per hour. The primary outcome is the amount of anaesthetic consumed, the decrease in liquid desflurane (SupraneR) in the vaporiser of the ananesthetic machine. The vaporizer will be weighed before and after the anaesthetic to define the amount used.
Asys	Asys, a anaesthetic machine with a bag/bellow for compression of gas to be insufflated	Wash in of desflurane (Suprane) in conventional anaesthesia machine Asys, with the anaesthesia machine Asys that has a bag/reservoir that is compressed for insufflation of gas into the patient, thus it is expected that more gas will be consumed per hour. The primary outcome is the amount of anaesthetic consumed, the decrease in liquid desflurane (SupraneR) in the vaporiser of the ananesthetic machine. The vaporizer will be weighed before and after the anaesthetic to define the amount used.

Primary Outcome Measures

Name	Time	Method
Time to reach 1.5 MAC (minimal alveolar concentration) Et	1 hour	The time needed, seconds, to increase the end tidal desflurane concentration during wash-in from a 1 MAC to a 1.5 MAC with a constant fresh gas flow of 1 L/min and the vaporiser set a 3 MAC ( minimal alveolar concentration) (18%) will be compared between the two study groups

Secondary Outcome Measures

Name	Time	Method
amount of inhaled agent consumed ml/min	5 hours	The vaporiser will be weighed before and after each case and the amount of vapor, desflurane, consumed during the anaesthesia will be calculated Gr/min.
Postoperative Quality of Recovery	72 hours	Quality of recovery will be followed during the first 72 hours after anaesthesia

Trial Locations

Locations (1)

Danderyds Hospital; 🇸🇪 Stockholm, Sweden