Prevention of change of gastric Ph(acidity) and volume during laparoscopic cholecystectomy(removal of diseased gall bladder due to gall stone disease) by intravenous rabeprazole(Antacid)in patients during general anaesthesia to minimize risk of gastric aspiration and injury to lungs
Not Applicable
- Conditions
- Health Condition 1: K801- Calculus of gallbladder with othercholecystitis
- Registration Number
- CTRI/2022/12/048045
- Lead Sponsor
- VCSGGMS and RI Srikot Srinagar Garhwal Uttarakhand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patient with American Society Of Anaesthesia Grade 1 and 2 undergoing laproscopic cholecystectomy under general anaesthesia
Exclusion Criteria
EXCLUSION CRITERIA- Patient with gastric reflux, peptic ulcer hiatal hernia,liver disease with deranges liver function, hypersensitivity to pantoprazole will be excluded from study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br/ ><br> A)To study effect/ action of intravenous rabeprazole on gastric pH and volume during laparoscopic cholecystectomy. <br/ ><br>Timepoint: The gastric aspirates for pH (3ML) and volume and measurement will be collected through Ryleâ??s tube (16G).Colour of samples will be noted. <br/ ><br>i) At the end of 8 hrs of fasting period before inj rabeprazole-TIME-0 <br/ ><br> ii) Post Induction 5minutes Before CO2 insufflation <br/ ><br> iii) 5 minutes Post CO2 Inflation than Half hrly perioperatively <br/ ><br> iV) Post CO2 deflation 5 ,10 ,15minuts and 30 minutes perioperatively <br/ ><br> V) I/2 hr & 1hr after extubation. <br/ ><br>
- Secondary Outcome Measures
Name Time Method <br/ ><br>Incidence of Perioperative duodenal gastric regurgitation during laparoscopic cholecystectomy <br/ ><br> C)Postoperative nausea vomiting <br/ ><br> <br/ ><br>Timepoint: i)At the end of fasting period before inj rabeprazole <br/ ><br>ii)Post Induction Before CO2 insufflation <br/ ><br>iii)Post CO2 Inflation Halfhrly perioperatively <br/ ><br>iV)Post CO2 deflation perioperatively <br/ ><br>V)1/2 hr & 1hr after extubation. <br/ ><br>