Polycystic Ovary Syndrome With Periodontal Disease and Dental Caries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 206
- 试验地点
- 1
- 主要终点
- 17-OH-progesterone
研究概览
简要总结
This study evaluates the oxidative stress parameters in females with polycystic ovary syndrome (PCOS) and clinically healthy. Because of the fact that both oral disease included periodontitis and dental caries, and metabolic syndrome are associated with systemic inflammation, these two disorders may be linked through a common pathophysiologic pathway
详细描述
Power analysis was performed with the G-Power software package to determine sample size. To cover possible data loss, 10% of a group were added to each group. Medical and dental examination will be performed both of control and experimental groups. Age and body mass index (BMI) will be recorded.
In dental examination decayed, missing, or filled teeth (DMFT) index will be used according to World Health Organization (WHO 1997) criteria. All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II). To analyze the correlation between oral health status and polycystic ovary syndrome linear regression test and for comparison of both the groups (case and control), two sample t test and chi square test were used.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 24 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •females with Polycystic Ovary Syndrome
排除标准
- •history of ovarian surgery, patients with thyroid or prolactin hormone level abnormalities, non-classic 21-hydroxylase deficiency and hormonal therapy, steroid drug use past 6 months, obese patients (body mass index, BMI > 35), acute or chronic upper respiratory tract diseases, dental fluorosis, patients using fluoride supplements or orthodontic appliances will not be included in the study.
结局指标
主要结局
17-OH-progesterone
时间窗: 1 day
17-OH-progesterone is tested by blood sample 20-100 ng/dL
luteinizing hormone
时间窗: 1 day
luteinizing hormone \[LH\] is tested by blood sample 1.68-15 U/L
FSH hormone ovarian morphology (PCOM)
时间窗: 1 Day
follicle-stimulating hormone \[FSH\] is tested by blood sample 6.3_24 mlu/ml
dehydroepiandrosterone-sulfate
时间窗: 1 day
dehydroepiandrosterone-sulfate \[DHEA-S\] is tested by blood sample 65 to 380 µg/dL or 1.75 to 10.26 µmol/L
次要结局
- Clinical attachment level(1 Day)
- Plaque Examination(1 Day)
- dental examination(1 Day)
- periodontal examination(1 Day)
- Bleeding Examination(1 Day)
- Gingival Examination(1 Day)
研究者
Gul Yildiz Telatar
Assistant Professor
Recep Tayyip Erdogan University Training and Research Hospital