跳至主要内容
临床试验/NCT02604927
NCT02604927Unknown不适用

Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury

University of Sao Paulo1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2016年2月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
20
试验地点
1
主要终点
Exercise performance (Time to exhaustion test)

研究概览

简要总结

Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from artificially induced alkalosis than lower-body muscle groups. Although β-alanine appears to be an interesting and potential ergogenic supplement for paralympians, no study to date has assessed its potential in wheelchair athletes.In this study, we will evaluate the effects of β-alanine supplementation on upper-body performance in wheelchair athletes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Male
接受健康志愿者
是

入选标准

  • •Paralympian training for any exercise modality for at least one year;
  • •A weekly training volume of 6 hours or more;
  • •Have a spinal cord injury accompanied by loss of motor function in the lower limbs for at least one year;
  • •Available for carrying out the experimental procedures.

排除标准

  • •Use of creatine or beta-alanine for at least 3 and 6 months before the trial;
  • •Cardiovascular or respiratory disease;
  • •Clinical condition that result in malabsorption of nutrients;
  • •Any other medical condition that prevents the realization of experimental procedures.

研究组 & 干预措施

Beta-alanine

Experimental

800 mg of beta-alanine, four times per day, during 28 days.

干预措施: Beta-alanine (Dietary Supplement)

Placebo

Placebo Comparator

800 mg of dextrose, four times per day, during 28 days.

干预措施: Dextrose (Dietary Supplement)

结局指标

主要结局

Exercise performance (Time to exhaustion test)

时间窗: 28 days

Time to exhaustion test performed on arm crank ergometer

Muscle carnosine content before and after supplementation

时间窗: 28 days

Assessed by muscle biopsy samples before performance tests

次要结局

  • Safety of beta-alanine supplementation measured by complete hemogram analysis(28 days)
  • Blood pH.(5 minutes after performance tests)
  • Muscle carnosine content in trained (deltoid) vs. untrained (vastus lateralis) muscles(28 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bruno Gualano

Professor

University of Sao Paulo

研究点 (1)

Loading locations...

相似试验