Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Exercise performance (Time to exhaustion test)
研究概览
简要总结
Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from artificially induced alkalosis than lower-body muscle groups. Although β-alanine appears to be an interesting and potential ergogenic supplement for paralympians, no study to date has assessed its potential in wheelchair athletes.In this study, we will evaluate the effects of β-alanine supplementation on upper-body performance in wheelchair athletes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Paralympian training for any exercise modality for at least one year;
- •A weekly training volume of 6 hours or more;
- •Have a spinal cord injury accompanied by loss of motor function in the lower limbs for at least one year;
- •Available for carrying out the experimental procedures.
排除标准
- •Use of creatine or beta-alanine for at least 3 and 6 months before the trial;
- •Cardiovascular or respiratory disease;
- •Clinical condition that result in malabsorption of nutrients;
- •Any other medical condition that prevents the realization of experimental procedures.
研究组 & 干预措施
Beta-alanine
800 mg of beta-alanine, four times per day, during 28 days.
干预措施: Beta-alanine (Dietary Supplement)
Placebo
800 mg of dextrose, four times per day, during 28 days.
干预措施: Dextrose (Dietary Supplement)
结局指标
主要结局
Exercise performance (Time to exhaustion test)
时间窗: 28 days
Time to exhaustion test performed on arm crank ergometer
Muscle carnosine content before and after supplementation
时间窗: 28 days
Assessed by muscle biopsy samples before performance tests
次要结局
- Safety of beta-alanine supplementation measured by complete hemogram analysis(28 days)
- Blood pH.(5 minutes after performance tests)
- Muscle carnosine content in trained (deltoid) vs. untrained (vastus lateralis) muscles(28 days)
研究者
Bruno Gualano
Professor
University of Sao Paulo
