Randomized controlled study of Liuwei Dihuang capsule in the treatment of yin deficiency syndrome of Alzheimer's disease
- Conditions
- Alzheimer disease
- Registration Number
- ITMCTR2100004335
- Lead Sponsor
- Traditional Chinese Pharmacological Laboratory, School of Traditional Chinese Medicine, Southern Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) Aged 50-85 years;
(2) According to the core clinical diagnostic criteria of Alzheimer's disease dementia (2011) of National Institute on aging and Alzheimer's Association (nia-aa) or mild cognitive impairment caused by Alzheimer's disease (2011); according to the diagnostic scale of yin deficiency syndrome of Alzheimer's disease, it was judged as yin deficiency syndrome; the course of memory loss was more than 6 months and confirmed by others The possible manifestations of AD (asymmetric atrophy of medial temporal lobe or hippocampus, etc.) were found on MRI scan;
(3) Graduated from primary school or above, able to complete relevant tests and inspections;
(4) The patients with mild and moderate condition: the total score of mini mental state examination >= 11 and < 27; the total score of clinical dementia rating scale >= 0.5 and <= 2; the total score of haginsky ischemia scale <= 4;
(5) There are stable and reliable caregivers; voluntary and legal guardians agree to participate, and jointly sign the informed consent.
(1) Dementia caused by other reasons;
(2) severe cardiovascular system, respiratory system, digestive system, endocrine system, severe liver and kidney dysfunction;
(3) Those who are definitely diagnosed with depression, anxiety and other mental diseases or are taking anti anxiety and depression drugs; take other traditional Chinese medicine containing experimental traditional Chinese medicine ingredients within one month;
(4) Other situations that the researchers think are not suitable to participate in this study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method