Study for Syndrome Differentiation of Traditional Chinese Medicine in the Treatment of Parkinson's Disease With Deep Brain Stimulation: a Randomized Controlled Tiral

Yuquan Hospital of Tsinghua University0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1. Patients aged 45-75 years old with primary Parkinson's disease after DBS;
•2. Patients whose course of Parkinson's disease is 5 years or more;
•3. Hoehn Yahr (H-Y) was divided into two or more stages under the condition of off (not taking medicine);
•4. UPDRS score >= 30 in off state;
•5. The patients who respond well to dopamine drugs and improved the UPDRS score of acute levodopa test more than 30% (medoba 250mg);
•6. Patients whose daily drug clearance period is at least 6 hours, or who have serious movement complications such as abnormal movement, and who can not be effectively improved by repeated adjustment of drugs;
•7. Patients with MMSE score >= 24.

•1. Patients who have received surgery for Parkinson's disease other than deep brain stimulation, such as stereotactic lesion, cell transplantation, gamma knife, etc.;
•2. Off state has severe middle line symptoms such as language disorder, dysphagia and balance disorder;
•3. There are contraindications of Neurosurgery, such as cerebral infarction, hydrocephalus, brain atrophy, ventricular enlargement, sequelae of cerebrovascular disease, heart disease, severe thrombocytopenia and other cardiovascular and cerebrovascular diseases;
•4. Patients with other concomitant diseases who have or need to be implanted with pacemakers, defibrillators, cochlear implants and other nerve stimulators;
•5. Patients with tumor, serious abnormality of liver function and kidney function (index more than three times of normal value) and other concomitant diseases that seriously affect health.

发起方

Yuquan Hospital of Tsinghua University