NL-OMON42085招募中不适用
Feasibility Study to Identify the Optimal Adjuvant Combination Scheme of Ipilimumab and Nivolumab in resectable stage III melanoma patients (OpACIN) - Study to identify the Optimal Adjuvant Scheme in melanoma patients (OpACIN)
ederlands Kanker Instituut0 个研究点目标入组 20 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Adults at least 18 years of age
- •World Health Organization (WHO) Performance Status 0 or 1
- •Histologically confirmed resectable stage III melanoma with palpable lymph node metastases and no history or active in-transit metastases within the last 6 months
- •Patient willing to undergo triple tumor biopsies during screening and in case of disease progression
- •No prior immunotherapy targeting CTLA-4, PD-1 or PD-L1
- •No immunosuppressive medications within 6 months prior study inclusion
- •Presence of at least two of the defined HLA alleles
- •Screening laboratory values must meet the following criteria: WBC >= 2.0x109/L, Neutrophils >=1.5x109/L, Platelets >=100 x109/L, Hemoglobin >=5.5 mmol/L, Creatinine <=1.5x ULN, AST <= 1.5 x ULN, ALT <= 1.5 x ULN, Bilirubin <=1.5 X ULN
- •normal LDH
- •Women of childbearing potential (WOCBP) must use appropriate method(s) of contraception. WOCBP should use an adequate method to avoid pregnancy for 23 weeks (30 days plus the time required for nivolumab to undergo five half-lives) after the last dose of investigational drug
- •Women of childbearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours prior to the start of ipilimumab+nivolumab
- •Men who are sexually active with WOCBP must use any contraceptive method with a failure rate of less than 1% per year Men who are sexually active with WOCBP will be instructed to adhere to contraception for a period of 31 weeks after the last dose of investigational product
- •Women who are not of childbearing potential (ie, who are postmenopausal or surgically sterile as well as azoospermic men do not require contraception
排除标准
- •Distantly metastasized melanoma
- •Subjects with any active autoimmune disease or a documented history of autoimmune disease, or history of syndrome that required systemic steroids or immunosuppressive medications, except for subjects with vitiligo or resolved childhood asthma/atopy
- •Prior CTLA-4 or PD-1/PD-L1 targeting immunotherapy
- •Radiotherapy prior or post surgery within this trial
- •Patients will be excluded if they are positive test for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV antibody) indicating acute or chronic infection
- •Patients will be excluded if they have known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
- •Allergies and Adverse Drug Reaction
- •- History of allergy to study drug components
- •- History of severe hypersensitivity reaction to any monoclonal antibody
- •Underlying medical conditions that, in the Investigator's opinion, will make the administration of study drug hazardous or obscure the interpretation of toxicity determination or adverse events;
- •Concurrent medical condition requiring the use of immunosuppressive medications, or immunosuppressive doses of systemic or absorbable topical corticosteroids;
- •Use of other investigational drugs before study drug administration 30 days and 5 half-times before study inclusion
- •Pregnant or nursing
研究者
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