The Effect of Aortic Impedance on Myocardial Relaxation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- heart myocardium relaxation (diastole)
研究概览
简要总结
Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?
详细描述
60 subjects, 30 with hypertension and 30 without will attend two visits to the GCRC. At each visit, pulsatile hemodynamics (by using tonometry-a non-invasive means to obtain arterial pressure tracings) and Doppler tissue imaging relaxation velocity (a measurement of myocardial relaxation obtained by echocardiography) data will be collected before and after administration of vasodilator medication. At the first visit, each patient will receive an oral dose of the vasodilator hydralazine (does not effect aortic stiffness), and at the second visit each patient will receive intravenous nesiritide (does effect aortic stiffness). The relationship between timing of the reflected pulse wave and myocardial relaxation velocity will be studied at baseline and following administration of each vasodilator to determine if changing aortic stiffness has an impact on myocardial relaxation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects over the age of 65
排除标准
- •Have known or suspected coronary artery disease
- •Have known or suspected left ventricular dysfunction
- •Have significant valvular, infiltrative, pericardial, or congenital heart disease
- •Have a resting systolic blood pressure < 100 mmHg
- •Have had an adverse reaction to nesiritide or hydralazine
- •Have a serum creatinine > 2 mg/dl at Visit 1
结局指标
主要结局
heart myocardium relaxation (diastole)
时间窗: before and after administration of vasodilator medication
次要结局
未报告次要终点