EUCTR2013-001147-31-DK
Active, not recruiting
Not Applicable
Aortic Valve Stenosis and Myocardial Efficiency – a Prognostic Marker and a Target for Intervention? - MELVAS
Aarhus University Hospital, Department of Cardiology0 sitesJune 6, 2013
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aortic stenosis
- Sponsor
- Aarhus University Hospital, Department of Cardiology
- Status
- Active, not recruiting
- Last Updated
- 10 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Aortic valve area \<1,2 cm2 and/or transaortic maximal velocity (VmaxAO) of 3,0\-5,0 m/s
- •\- Sinus rhythm \>60/min after 5 minutes rest
- •\- LVEF \>55%
- •\- Male or female
- •\- Age 20\-100 years old
- •\- Safe birth control management (intrauterine devices or hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release))
- •\- Negative urine\-HCG for women of childbearing potential
- •\- Ability to understand the written patient information and to give informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
Exclusion Criteria
- •\- Systolic BP \<100 mmHg after 5 minutes of rest
- •\- Left ventricular posterior wall thickness \>17 mm
- •\- Signs or history of myocardial infarction and/or severe ischemic heart disease
- •\- Severe asthma or chronic obstructive pulmonary disease
- •\- New York Heart Association (NYHA) classification \> I due to AS
- •\- NYHA \> II due to non\-cardiac causes
- •\- 2? or 3? atrioventricular block
- •\- Ongoing beta\-blocker therapy
- •\- Ongoing verapamil or diltiazem therapy
- •\- Ongoing monoamine oxidase inhibitors therapy
Outcomes
Primary Outcomes
Not specified
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