ACTRN12613000083796招募中未知
In patients with severe Aortic Stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI), what associated neurological injury exists as measured radiologically (magnetic resonance imaging), serological markers of neurological injury (s100B and GFAP) and clinically (neurological assessment, neurocognitive assessment, health-related quality of life scales).
Critical Care Research Group (CCRG)0 个研究点目标入组 80 人开始时间: 2013年1月22日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- o limit 至 o limit（—）
- 性别
- All
入选标准
- •All consenting patients undergoing transcatheter aortic valve implantation (TAVI) via the transfemoral, transaortic and transapical routes with the Edwards SAPIEN-XT valve under general anaesthetic.
排除标准
- •1. Lacks capacity to consent for him or herself.
- •2. Pre-existing neurological impairment measured as modified Rankin Score >=3.
- •3. Contraindication to MRI (including incompatible metallic prosthesis/foreign body, inability to lie flat, claustrophobia requiring sedation)
- •4. Non or poor English-speaking due to nature of cognitive testing and unknown validity in such populations
- •5. Previous aortic valve repair/replacement.
- •6. Coronary artery disease requiring revascularisation (including patients undergoing combined AVR and CABG).
研究者
相似试验
进行中（未招募）
不适用
Mechanisms of excess risk in aortic stenosis after aortic valve replacementSevere symptomatic aortic stenosisCirculatory SystemAortic (valve) stenosisISRCTN64700462niversity College London192
进行中（未招募）
1 期
sefulness of Ivabradine in the diagnosis of valvular heart disaease.Aortic valve stenosis with reduced ejection fractionMedDRA version: 19.0 Level: PT Classification code 10002918 Term: Aortic valve stenosis System Organ Class: 10007541 - Cardiac disordersEUCTR2016-002015-17-DKOdense University Hospital25
招募中
不适用
WItten heaRt failurE in Aortic Stenosis study - Prospective diagnostic study to investigate the hemodynamic basis of an irreversible left ventricular failure in severe aortic stenosisI35.0I42.8Aortic (valve) stenosisOther cardiomyopathiesDRKS00009993Kardiogische Klinik, Marien-Hospital Witten, Ruhr-Universität Bochum40
已完成
不适用
A study on the rate of aortic valve stenosis in patients with left ventricular hypertrophy in preoperative electrocardiogramAortic valve stenosisJPRN-UMIN000034965Kindai University Faculty of Medicine Department of Anesthesiology236
尚未招募
Unknown
Examining the feasibility of implementing of an evidence-based Frailty Response Program in hospital settings for frail adults with aortic stenosis undergoing heart valve replacement procedures (FRAIL-AS Response Trial)FrailtyTranscatheter aortic valve implantationValvular heart diseaseCardiovascular - Other cardiovascular diseasesSurgery - Other surgeryAortic stenosisACTRN12624000318583Australian Catholic University250