ISRCTN64700462
Active, not recruiting
未知
Mechanisms of excess risk in aortic stenosis after aortic valve replacement: a prospective single-centre observational cohort study
niversity College London0 sites192 target enrollmentMarch 15, 2021
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Severe symptomatic aortic stenosis
- Sponsor
- niversity College London
- Enrollment
- 192
- Status
- Active, not recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Able to provide written informed consent
- •2\. Patients with symptomatic, severe AS referred for surgical or transcatheter AVR with one out of the following echocardiographic criteria for severe AS:
- •2\.1\. Effective orifice area \[EOA] \<1\.0 cm²
- •2\.2\. Indexed EOA of 0\.6 cm²/m²
- •2\.3\. Peak velocity \>4\.0 m/s or mean gradient \>40 mmHg
Exclusion Criteria
- •1\. More than moderate valve disease other than AS
- •2\. Patients that have a conventional contraindication for CMR (non\-MR conditional pacemakers/implantable defibrillators, claustrophobia)
- •3\. Renal impairment (creatinine clearance \<30 ml/min/1\.73m²)
- •4\. Needle phobic patients that would preclude blood taking
- •5\. Diagnosis of dilated or hypertrophic cardiomyopathy
- •6\. Pregnancy/breastfeeding, eGFR \<30 ml/min
- •7\. Inability to complete the protocol, other conditions that would prevent participation in the study.
- •8\. Adenosine stress perfusion will not be performed in those patients with:
- •8\.1\. Asthma/COPD of sufficient severity to make adenosine contraindicated
- •8\.2\. High\-grade conduction disease precluding the use of adenosine
Outcomes
Primary Outcomes
Not specified
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