Is the hypothalamic neural activity disturbed in patients with familial combined hyperlipidemia?

• Conditions: familial combined hyperlipidemia; 10011082; 10013317

• Registration Number: NL-OMON31970
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

Male patients (index patients in protocol B) with proven FCH (combined hyperlipidemia, premature atherosclerosis, positive family history for dyslipidemia and premature mortality (before age of 55 yrs))
Age 18-60 yr

Exclusion Criteria

BMI > 25 kg/m2 or BMI < 19 kg/m2
Current or past history of alcohol intake > 2E/day
Smoking
Presence of active disease or past disease (that may affect variables measured in this protocol)
Irregular diet habits
Slimming or having a diet on medical indication
Medication (including those with central activity, e.g. antidepressants)
Claustrophobia
Diabetes or a family history positive for diabetes
Metal implants or metal objects that cannot be removed (e.g. piercings)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. differences in hypothalamic neural activity (and suppressive effect after<br /><br>oral glucose load) between patients with FCH and healthy volunteers</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>mean change (in %) in beat-to-beat variation (lead III heart rhythm recording)<br /><br>during study protocol</p><br>