Study of the communication of the hypothalamus with the periphery: impact of metformin on leptin transport in the cerebrospinal fluid of obese patients. A monocentric prospective study - LEPTOB

Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL)0 个研究点目标入组 31 人开始时间: 2018年11月5日最近更新: 2024年4月22日

适应症

试验速览

暂无简介。

•- Male or female aged > = 18 and < = 40 years
•- Patient having an obesity with BMI > 30
•- Patient beneficiary of the French National Health Fund
•- Patient having agreed to take part in the study and having signed written consent form
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 31
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•-Type 2 diabetes defined by 2 fasting blood glucose > 1,26 g/L or blood glucose > 2g/L at 120min of oral glucose tolerance test with 75g of glucose)
•- Glucose intolerance (fasting blood glucose between 1,10g/L and 1,26g/L or blood glucose between 1,40g/L and 2g/L at 120 minutes of oral glucose tolerance test with 75g of glucose)
•- Patients who are already treated with metformin
•- Type 1 diabetes
•- Active neoplastic pathology whose diagnosis is <5 years or under treatment
•- Neurological pathology (demyelinating, tumoral, vascular)
•- Pathology of adipose tissue (lipodystrophy)
•- History of bariatric surgery
•- Contraindication to metformin at the maximum dose
•- Contraindication to lumbar puncture
•- Contraindication to MRI

发起方

Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL)