Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial
Not Applicable
Recruiting
- Conditions
- Weight Gain
- Interventions
- Other: weight gain each group
- Registration Number
- NCT06288854
- Lead Sponsor
- Rajavithi Hospital
- Brief Summary
* Efficacy of olanzapine on weight gain in advanced stage gynecologic cancer
* Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo
- Detailed Description
-Proprotion of pateints in advanced stage gynecologic cancer who recieving paclitaxel and carboplatin chemotherapy gain weight on olanzapine or placebo
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 48
Inclusion Criteria
- Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy
- ECOG 0-1
- Normal CBC,Liver, renal function
- Communication in Thai language or Thai caregiver
- Inform consent
Exclusion Criteria
- Pregnancy
- Active infection
- Bowel obstruction or history of bowel surgery
- On dopamine receptor antagonists or psychiatric or anticonvulsant medication
- Olanzapine allery
- Abnormal function of liver and renal
- Diabetic melitus or morbid obesity
- patient can't selfcare
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Olanzapine weight gain each group Olanzapine 5 mg oral OD Placebo weight gain each group Placebo
- Primary Outcome Measures
Name Time Method Efficacy of olanzapine on weight gain in advanzed stage gynecologic cancer recieving paclitexal and carboplatin chemotherapy 12 weeks after intervention proprotion of pateints gain weight after intervention (olanzapine or placebo) by monitor weight before and after get intervention
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rajavithi Hospital
🇹🇭Bangkok, Thailand