Functional Imaging of Social Cognition in Premanifest Huntington's Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- Significant group differences in brain activation for perceiving emotional vs neutral faces by following random effects analyses
研究概览
简要总结
Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures. The symptoms of HD include involuntary movements, cognitive deterioration and behavioural disturbances. It has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (preHD). This deficit in perception of emotions has been primarily investigated by means of facial expressions. However, emotions can also be expressed through body language. Here, the investigators propose to investigate whether the emotion comprehension deficit in preHD also includes body language comprehension.
详细描述
The investigators will perform a detailed evaluation of body language comprehension abilities in persons that carry the genetic mutation causing HD, but who do not show any movement symptoms yet. In addition, the associated changes in brain structure and function will be studied. The aim is to perform the study with the same group of participants who participated in a recent study carried on by this research group, in which the functional brain changes associated with increased irritability were investigated. This will allow to relate emotion experience with emotion perception. The results of the study may provide a target to further develop therapeutic interventions and aid caregivers of preHD subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Huntington's disease positive genotype and non-carrier siblings
排除标准
- •visible chorea
- •MRI contra-indications
- •major neurological/psychiatric comorbidity
结局指标
主要结局
Significant group differences in brain activation for perceiving emotional vs neutral faces by following random effects analyses
时间窗: 6 months
Significant group differences in beta-values for the contrast emotional faces vs neutral faces following general linear model parameter estimates
次要结局
未报告次要终点
研究者
Jan Van den Stock
Post-doctoral researcher
Universitaire Ziekenhuizen KU Leuven