Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- the achievement of social cognition process in Huntington's disease using the total score of the scale 15-TOM
研究概览
简要总结
Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by movement disorders, cognitive and behavioral. The social behavior of patients are changed, affecting interpersonal relationships. Patients with Huntington's disease are described as self-centered, lacking sympathy and empathy and mentally inflexible. These behavioral problems can be a major source of anxiety for patients and their families. These disorders also have a negative impact cognitive and motor symptoms as well as the functional abilities and the quality of life of patients and their entourage. Authors have suggested that these problems could be related inter alia to social cognition disorders. This concept refers to a set of skills and emotional and social experiences that regulate relations between individuals and can explain the behavior of individuals and groups. The objective is to evaluate disorders of social cognition, which may account for behavioral changes in Huntington's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For all particpipants
- •Patient gave its written consent
- •between 20 and 70 years
- •School level : at least 7 years
- •native language: french
- •For presymptomatic patient
- •Huntington's disease diagnosed with abnormal number of CAG repeats: 36 < nucleotide expansion (CAG)
- •Unified Huntington Disease Rating Scale moteur ≤ 5
- •For symptomatic patient
- •Huntington's disease diagnosed with abnormal number of CAG repeats: 36 < nucleotide expansion (CAG)
- •Unified Huntington Disease Rating Scale moteur > 5
排除标准
- •No national health insurance affiliation
- •Being under guardianship
- •Meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body, Renal failure, hypersensitivity of Gadolinium) or refusing MRI
- •Pregnant or lactating women
- •Patient with involuntary movement hampering the realization of MRI
结局指标
主要结局
the achievement of social cognition process in Huntington's disease using the total score of the scale 15-TOM
时间窗: 3 months after inclusion
次要结局
未报告次要终点