Effect of administration of Busulfan and Cyclophosphamide on liver toxicity after Allogenic Hematopoietic Stem Cell Transplantatio

Not Applicable

• Conditions: acute leukemia.; acute lymphoblastic leukemia; acute myeloblastic leukemia; c91.0; c92

• Registration Number: IRCT2014060517982N1
• Lead Sponsor: Shiraz University Of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

patients with acute leukemia; patients that are candidate for allogenic Hematopoeitic Stem Cell Transplantation(HSCT) and Exclusion criteria: patients with disease other than acute leukemia; patients with transplantation other than myeloablative HSCT; patients without regular follow up

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
iver function test. Timepoint: before intervention , every other day during hospitalization , weekly till day +100. Method of measurement: IU/L with photometric assay.

Secondary Outcome Measures

Name	Time	Method
Graft versus host disease and veno-occlusive disease. Timepoint: daily during hospitalization and weekly till day +100 post transplantation. Method of measurement: liver function test and Glucksberg grading.