Accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease: the eGFR-C study

Not Applicable

Completed

• Conditions: Topic: Renal and Urogenital; Subtopic: Renal and Urogenital (all Subtopics); Disease: Renal; Urological and Genital Diseases; Chronic kidney disease, stage 3

• Registration Number: ISRCTN42955626
• Lead Sponsor: niversity of Birmingham (UK)

Brief Summary

2014 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/24423077 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31084924/ (added 10/08/2020) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/39056437/ (added 29/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10-08
• Study Completion: 2020-06-30
• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1320

Inclusion Criteria

1. Male and female, aged 18 years or over
2. Patients with stage 3 CKD (GFR 30-59 mL/min/1.73 m2) as defined internationally, diagnosed using Modification of Diet in Renal Disease/Chronic Kidney Disease Epidemiology Collaboration (MDRD/CKD EPI) eGFR (at least two consecutive test results in this range at least 90 days apart, with the most recent test in the last 12 months)
3. Written informed consent

Exclusion Criteria

1. History of untoward reactions to iodinated contrast media or allergy to topical iodine
2. Episode of acute kidney injury in previous 6 months (as defined by the Acute Kidney Injury Network criteria)
3. Amputation of whole or part limb
4. Pregnant or breastfeeding
5. Known alcohol or drug abuse
6. Any clinical condition with an expected survival of less than study duration
7. Inability to comply with study schedule and follow-up
8. Inability to provide informed consent e.g. due to cognitive impairment

Study & Design

• Study Type: Observational
• Study Design: Not specified