Role of the Radiologist in Management of Pulsatile Tinnitus

Not Applicable

• Conditions: Pulsatile Tinnitus (Diagnosis)
• Interventions: Device: Colour doppler,MSCT,MRI

• Registration Number: NCT05338684
• Lead Sponsor: Mohab Mohammed

Brief Summary

The aim of this study is to detect the role of interventional radiology in management of Pulsatile tinnitus and to detect the best imaging modality for Diagnosis.

Detailed Description

Tinnitus is a broad and complex subject concerning a symptom rather than a syndrome or a disease (1 ),New studies indicate that prevalence of tinnitus is 14.5% among those less than 40 years old and 17.5 - 35% among age over 40 years Old( 2-3 ). Vascular tinnitus causes are multiple , Arterial causes like Atherosclerosis , Fibromuscular dysplasia or Dissection of the carotid or vertebral artery , Arteriovenous causes like Cerebral head and neck arteriovenous malformation , Dural arteriovenous fistula and Carotid cavernous fistula Venous like Systemic diseases with hyperdynamic circulation . Chronic anemia, pregnancy, thyrotoxicosis , Idiopathic intracranial hypertension and Dural venous sinus stenosis , Tumors also like Paraganglioma which Some authors believe that para-gangliomas are the most common cause of vascular tinnitus and Vascular metastasis And other Miscellaneous Causes like Paget's disease m Otosclerosis or Otomastoiditis , but others see dural arteriovenous fistula (AVF) ,idiopathicvenous tinnitus, or idiopathic intracranial hypertension the most common causes. (4 - 9) , Also One of the Most important Arterial causes is Atherosclerosis , Atherosclerotic plaques ma produce turbulence of carotid flow and occasionally cause pulsatile tinnitus (10 ) , FMD ( Fibromuscular Dysplasia ) seen in 0.5% to0.6% of carotid angiograms and autopsies, is the second most common cause of extracranial carotid narrowing (11) information obtained from both CT and MRI is complementary In some casesThe angiographic findings may include luminal stenosis, abrupt reconstitution of the lumen, dissecting aneurysm, intimal flap, slow flow, occlusion, and distal emboli (12-15)

Study Timeline

• Status Verified: 2022-04
• Study First Submitted: 2022-04-02
• Study First Submitted QC: 2022-04-16
• Last Update Submitted: 2022-04-16
• Study Start: 2022-04-17
• Study First Posted: 2022-04-21
• Last Update Posted: 2022-04-21
• Primary Completion: 2023-11
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients with pulsatile tinnitus of unknown origin referred by a physician to diagnostic radiology to be assessed by imaging will be included in the study.
• Patient's with clinical diagnosed pulsatile tinnitus.
• patient refused surgical intervention.

Exclusion Criteria

• History of allergy to the contrast media , Contraindication to MRI and Refusal to sign a consent
• Pregnant women
• patients with atherosclerosis cause only or vascular loop more than 50% in internal auditory canal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
diagnostic catheter intervention then therapeutic if indicated	Colour doppler,MSCT,MRI	-

Primary Outcome Measures

Name	Time	Method
Manage pulsatile tinnitus with catheter angiography to all vascular lesion	Baseline	Manage pulsatile tinnitus causes with no indication for surgical intervention or prolonged and follow up and detect reported cases with pulsatile tinnitus could be managed by therapeutic angiography rather than other invasive surgical maneuver or Medical treatment

Secondary Outcome Measures

Name	Time	Method
To assess the accuracy of best imaging modality to diagnose pulsatile tinnitus .	Baseline	Detect accurate cause of pulsatile tinnitus and the best imaging for diagnosis with measurement of the percentage of indicated patient for therapeutic angiography rather than surgical intervention or follow up with medical treatment .