Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis C
Not Applicable
Completed
- Conditions
- Beta Thalassemia Major
- Interventions
- Dietary Supplement: Spirulina
- Registration Number
- NCT02744547
- Lead Sponsor
- Tanta University
- Brief Summary
Thalassemics can develop liver fibrosis because of iron overload and hepatitis C infection. The latter is the main risk factor for liver fibrosis in transfusion dependent thalassemics. Excess liver iron is clearly recognized as a co factor for the development of advanced fibrosis in patients with hepatitis virus C infection. Hyaluronic acid serum levels correlate with histological stages of liver fibrosis in hepatitis C patients, so it has a good diagnostic accuracy as a non invasive assessment of fibrosis and cirrhosis.there is evidence that suggests Spirulina may help to protect against liver damage, cirrhosis and liver failure in those with chronic liver disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- multitransfused beta thalassemic children with and without super added hepatitis C virus (HCV) infection diagnosed by serological detection of HCV antibodies and HCV RNA by polymerase chain reaction.
Exclusion Criteria
- liver decompensation child younger than 3 years patients with hepatitis B infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description thalassemic children with hepatitis C Spirulina 30 multitransfused beta thalassemic children infected with hepatitis C virus diagnosed by serological detection of HCV-antibodies and HCV RNA by polymerase chain reaction will be given Spirulina in a dose of 250 mg/kg/day orally for 3 months.
- Primary Outcome Measures
Name Time Method serum hyaluronic acid levels 3 months
- Secondary Outcome Measures
Name Time Method liver function tests 3 months aspartate aminotransferase to platelet ratio index (APRI) 3 months
Trial Locations
- Locations (1)
Faculty of Medicine- Tanta University
🇪🇬Tanta, Gharbia, Egypt