Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)
研究概览
简要总结
This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive disorder (NCD) patients will be re-invited from our previous cohort (2013-2014) (N=488).
详细描述
Objectives: This study aims to investigate the cognitive changes in older adults with different cognitive statuses.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •SuperAgers are determined by the scores of global cognitive function. This ensured that the participants are divided by a measure relevant to the current study without directly biasing the results toward the domain of interest;
- •Normal aging: the cases with the scores of cognitive performance within 1.5 standard deviation (SD) of age and education matched normative values derived from our cohort study, of which presented with HK MoCA score greater than 26 and CDR score equal to 0;
- •NCD patients are defined as: evidence of modest decline in one or more cognitive domains, which is set as ≥ 1.5 SD below the age- and education-adjusted normative scores; no interference with independence in everyday activities; and no comorbid major psychiatric disorders.
排除标准
- •History of bipolar disorders or psychosis;
- •History of major neurological deficits including stroke, transient ischemic attack or traumatic brain injury;
- •Comorbidities with depressive symptoms.
结局指标
主要结局
Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)
时间窗: 2022-2024
The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.HK MoCA score less than 26 indicates cognitive impairments.
Complex attention will be measured by Attention Network Test (ANT)
时间窗: 2022-2024
Attention Network Test (ANT). The ANT paradigm (Download from: https://www.sacklerinstitute.org/cornell/assays_and_tools/ant/jin.fan/), as a computerized test, was used and performed by E-Prime 3.0 (Psychology Software Tools, PA, USA). Within ANT paradigm, there are four types of cue: no cue, center cue, double cue, and spatial cue; and three types of flanker: neutral, congruent, and incongruent. In a given trial, a central cross-fixation point presents for 400 to 1,600 ms (randomized), subsequently is replaced for 100 ms by one of four warning cues. The target, a central arrow could appear above or below the cross-fixation and is surrounded by two flankers on each side.
次要结局
- Learning and memory will be measured by Word list learning test (WLLT)(2022-2024)
研究者
LU Hanna
Assistant Professor
Chinese University of Hong Kong