Influence of Bacterial Growing Properties in Treatment of Acute Exacerbation Chronic Sinusitis
Phase 1
- Conditions
- Chronic rhinosinusitisJ32.9
- Registration Number
- RBR-4twfv7
- Lead Sponsor
- Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Subjects of both genders, adults (older than 18 years) routine followed by outpatient management with clinical signs and symptoms compatible with acute exacerbation of chronic rhinosinusitis. Voluntarily agree to participate in the study and signed an informed consent and informed.
Exclusion Criteria
Patients who have used oral or topical antibiotics in the last 30 days; systemic corticosteroids in the past 30 days, who are using systemic antihistamine, systemic or topical decongestants. Patients younger than 18 years, pregnant women, patients with allergy to any component of amoxicillin-clavulanate or carrying any serious disease.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected: To evaluate whether antibiotic therapy modifies the evolution of acute exacerbation of chronic sinusitis and if there is a relationship between the clinical condition and the presence of a biofilm-forming bacteria by comparisson of questionnaires daily symptoms, quality of life scores, nasal endoscopy and the detection of biofilm forming bacteria in nasal swab cultures by Calgary modified assay.;Found: Different methods of evaluation were concordant that patients treated with amoxicillin-clavulanate had clinical improvement, although there was no bacteriological cure at the end of treatment in most cases. Higher frequency of exacerbation and bad clinical outcome were associated with biofilm-forming bacteria.
- Secondary Outcome Measures
Name Time Method Expected: To identify the prevalence of biofilm-forming bacteria in patients with acute exacerbation chronic rhinosinusitis and<br>to compare the difference between minimum inhibitory concentration to antibiotics of planktonic forms and inhibitory concentration of biofilms to antibiotics of biofilm-forming bacteria by Calgary modified assay.;Found: Inhibitory concentration for biofilm-forming bacteria showed high rates of resistance to amoxicillin and clarithromycin for gram-negative bacteria, although amoxicillin-clavulanate and levofloxacin were effective inhibiting the growth of all bacteria.