Effect of Krishnadi churna and Madhutailik Basti in the management of Polycystic Ovarian Syndrome- Clinical Trial and In-silico study

Faculty of Ayurveda Institute of Medical Sciences BHU1 个研究点分布在 1 个国家目标入组 66 人开始时间: 2025年2月10日最近更新: 2026年2月7日

试验速览

阶段: 2 期
状态: 招募中
发起方
入组人数: 66
试验地点: 1
主要终点: B) Serum LH on day 2 or 3 of menses

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Polycystic Ovarian syndrome is the most prevalent endocrinopathy affecting women in the reproductive age group which has a negative impact on several organ systems and can lead to abnormal uterine bleeding, anovulation, altered serum lipid levels, acne, acanthosis nigricans, polycystic ovaries and infertility etc According to Ayurvedic classics, the whole deranged metabolic processes distributed in PCOS is considered as Dhatwagni Vikar or Bahudoshavastha, hence Basti therapy is given which pacifies Vata Dosha which in turn causes normalization of other doshas. PCOS is often referred to as a state of chronic inflammation , henceforth Krishnadi churna described in Charak Samhita in Shavathu chikitsa is given as a trial drug whose constituents posses potent anti inflammatory properties.

研究设计

研究类型: Interventional
分配方式: Randomized
盲法: None

入排标准

年龄范围: 16.00 Year(s) 至 40.00 Year(s)（—）
性别: Female

入选标准

•Female patients of Age group
•40 years. 2)Patients diagnosed with PCOS as defined by Modified Rotterdam Criteria ie if any two of the following are present (i)Clinical(Acne, hirsutism, hairloss) or Biochemical(raised total or free Testosterone ) evidence of hyperandrogenism. (ii) Oligo-Anovulation (Oligo-amenorrhoea (cycles more than 35 days apart or less than 8 menses a year ) (iii)Polycystic Ovarian Morphology ( more than or equal to 20 follicles per ovary in either ovary, more than or equal to 10 cm ovarian volume) 3) Both married and unmarried patients.

排除标准

•Patient of age less than 16 and above the age of 40 years.
•Patients with diagnosed cases of congenital malformation of uterus, adnexa or reproductive organs.
•Benign and Malignant lesion of reproductive organs.
•Endocrinal dysfunction like Thyroid Dysfunction, Adrenal Hyperplasia.
•Women with chronic ailments (systemic diseases like TB, DM, jaundice, bronchial asthma, cardiovascular diseases, Chronic liver Disease etc.).
•Patients with Anorectal disease like Haemorrhoids, fistula, fissures or having any history of psychological disorder.
•Patient having Acute pelvic inflammatory disease.
•Patient taking any hormonal therapy and history of Hormonal Contraception within 3 months prior to study , patient taking lipid lowering drugs or other drugs affecting Insulin Senstivity or Serum Androgen.