A clinical study to evaluate the effect of Latakaranjaadi Yoga in the management of PCOS

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy. It is a common metabolic-endocrine-reproductive disorder. PCOS is a heterogeneous disorder characterized by amenorrhea,oligo-ovulation or anovulation, signs of elevated androgen levels and multiple small ovarian cysts on one or both ovaries. The pathophysiology of PCOS involves primary defects in the hypothalamic-pituitary axis, insulin secretion and action, and ovarian function. Excess insulin stimulates the ovaries to produce large amounts of male hormone, testosterone which may prevent the ovaries from ovulating, thus causing infertility. Long course of disease without any management may reach the extreme in the form of Cardiovascular disorders, Endometrial cancer, hypertension, dyslipidemia, obesity, diabetes mellitus.

According to classics, PCOS cannot be correlated to a single entity. As PCOS itself says it is a group of symptoms. In Ayurveda there are many evidences which can mimic the features of Polycystic ovarian syndrome. Yonivyapads like Vandya. Artavavyapads like Nashtartava , Artava kshaya . It can also be correlated with Pushpaghni jaathaharini from Kashyapa Samhita. It leads to dosha dushya dusthi along with Medodushti and it adversely vitiates the Artava of women thus, making her infertile.

PCOS is a syndrome for which there is no permanent remission. Ovulation therapies and symptomatic treatments are practiced but complete cure is not attained. So there is increased demand to approach the problem from view of Ayurvedic system.

So in this thesis study is planned with the churna of Kuberaksha Beeja Majja, Shunthi, Methika, Rasona, Hingu, Sauvarchala Lavana, and Manjishta. These drugs are having katu, tikta rasa and usna virya, and vatakaphashamaka properties. Some of the drugs are also Mehaghana, and Vrishya in nature.

Hence these studied drugs may prove beneficial in the management of PCOS.