Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease

Not Applicable

• Conditions: Parkinson's Disease

• Registration Number: NCT02909192
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain limited. The proposed research will examine markers of the circadian system, sleepiness and sleep quality in PD patients. Further, the project will examine effects of bright light exposure on circadin function, sleep and alertness in PD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-09-15
• Study First Submitted QC: 2016-09-20
• Study First Posted: 2016-09-21
• Study Start: 2016-12
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-24
• Last Update Posted: 2020-11-27
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Parkinson's Disease Sleep Scale (PDSS-2) score to measure sleep quality	8 weeks

Secondary Outcome Measures

Name	Time	Method
Epworth Sleepiness Scale (ESS) score to measure daytime sleepiness	8 weeks
Plasma melatonin levels collected through blood samples to measure melatonin amplitude and circadian regulation	8 weeks
Non-Motor Symptoms Assessment Scale for Parkinson's Disease (NMSS) score to measure the severity and frequency of non-motor symptoms	8 weeks

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States