Bright Light Modulation of Non-motor Symptoms in Parkinson's Disease

Massachusetts General Hospital1 site in 1 country65 target enrollmentDecember 1, 2016

ConditionsParkinson's Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Parkinson's Disease
Sponsor: Massachusetts General Hospital
Enrollment: 65
Locations: 1
Primary Endpoint: Parkinson's Disease Sleep Scale (PDSS-2) score to measure sleep quality
Status: Active, not recruiting
Last Updated: 5 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain limited. The proposed research will examine markers of the circadian system, sleepiness and sleep quality in PD patients. Further, the project will examine effects of bright light exposure on circadin function, sleep and alertness in PD.

Registry

clinicaltrials.gov

Start Date

December 1, 2016

End Date

November 1, 2026

Last Updated

5 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Massachusetts General Hospital

Responsible Party

Principal Investigator

Aleksandar Videnovic, MD

Assistant Neurologist

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Parkinson's Disease Sleep Scale (PDSS-2) score to measure sleep quality

Time Frame: 8 weeks

Secondary Outcomes

Epworth Sleepiness Scale (ESS) score to measure daytime sleepiness(8 weeks)
Plasma melatonin levels collected through blood samples to measure melatonin amplitude and circadian regulation(8 weeks)
Non-Motor Symptoms Assessment Scale for Parkinson's Disease (NMSS) score to measure the severity and frequency of non-motor symptoms(8 weeks)