Evaluation of oxidative stress markers in hematopoietic stem cell transplantation patients
Not Applicable
- Conditions
- Hematologic disease
- Registration Number
- JPRN-UMIN000014412
- Lead Sponsor
- Yokohama Municipal Citizen's Hospital
- Brief Summary
19 male and 13 female patients with a median age of 58 years. In 20 allo-HSCT patients, the urinary 8-OHdG levels at 1 week after the transplant were significantly higher than the pre-conditioning levels and the levels in healthy controls. In 12 auto-HSCT patients, the urinary 8-OHdG levels at Week 1 were also higher than the pre-conditioning levels. The relative increase in the urinary-8OHdG levels from pre- to post-transplant at Week 1 was associated with a poor overall survival in the allo-HSCT patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who could not obtain written consent.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method