Exploring the effect of Continuous Positive Airway Pressure (CPAP) treatment withdrawal on markers of brain health and memory and thinking skills

Not Applicable

Recruiting

• Conditions: Obstructive Sleep Apnoea; Respiratory - Sleep apnoea

• Registration Number: ACTRN12619000721101
• Lead Sponsor: The Woolcock Institute of Medical Research, University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-05-14
• Last Update Posted: 25 November 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

•Be greater than 50 years old at time of assessment.
•Be fluent in English.
•Have been previously diagnosed with OSA.
•Be currently undertaking CPAP therapy for more than 3 months with good compliance.
•Be willing to attend appointments at both the Woolcock Institute of Medical Research
and Brain and Mind Centre.

Exclusion Criteria

•Have a suspected dementia or amnestic MCI on Telephone interview for the Cognitive
Status score of <31
•Have a history of stroke or other neurological disorder
•Have a current neurological or psychiatric condition (e.g. schizophrenia)
•History of cardiac atrial fibrillation
•Have an intellectual disability
•Have a current affective disorder (e.g. depression, anxiety)
•Are a shift-worker
•Have current or future plans for trans-meridian travel during the trial period
•Are currently taking any medications known to affect sleep
•Have any contraindications for MRI scanning (e.g. pacemaker)
•Do no demonstrate OSA symptom relapse (specifically apnoeas/hypoapnoeas)

Study & Design

• Study Type: Interventional
• Study Design: Not specified