Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sensitivity
- Sponsor
- University of Florida
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Sensory Function
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
Detailed Description
Despite the strong results of motor studies, the affects of AIH on sensory function has not been established. We will use a commercially-available hypoxicator that can be programmed to achieve a targeted level of arterial oxygen saturation. We plan to compare 3 previously published protocols that have generated motor facilitation (and a sham condition) to characterize and effects on sensory function in healthy adults.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 to 40 years of age
Exclusion Criteria
- •Diagnosis of cardiovascular disease (Hypertension, arrhythmias, coronary artery disease, congenital and valvar heart diseases)
- •Diagnosis of neuromuscular disease
- •Diagnosis of any neurological disease
- •Presence of concurrent medical illness including infection, fractures
- •Diagnosis of obstructive sleep apnea
- •Diagnosis of obstructive/restrictive lung disease
- •Diagnosis of exercise induced asthma
- •FEV1/FVC\<80% and/or FVC\<80% of predicted value indicating airway obstruction
- •Subjects on prednisolone therapy or selective serotonin reuptake inhibitor (SSRI) therapy will be excluded from the study as these pharmacological agents are known to amplify the effects of IH\[22, 23\]
- •Diagnosis of epilepsy or history of seizures and attention deficit disorders
Outcomes
Primary Outcomes
Sensory Function
Time Frame: Every 10 minutes for 60 minutes post intervention, average reported
Thermal thresholds. Average reported.
Temporal Sensory Summation
Time Frame: Every 10 minutes for 60 minutes post intervention, average reported
Temporal summation represents increases in ratings of pain intensity measured using a numeric pain rating scale (0-no pain to 100-worst pain imaginable) to repeated heat stimuli of the same intensity; that is, "summation" represents increases in participant ratings of pain despite the maintenance of a standard temperature and is calculated as the difference between pain rating 1 and pain rating 6. Positive difference scores indicate that pain reported increased over the 6 pulses of heat. Here, the average difference across participants and over time is reported.
Sensory Function - Pressure
Time Frame: Every 10 minutes for 60 minutes post intervention, average reported
Pressure threshold is the force at which the sensation of pressure first is considered painful by the participant, average reported