Parametric Mapping in Paediatric Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Parametric mapping values of normal subjects and patients
研究概览
简要总结
Magnetic resonance imaging (MRI) is increasingly an important tool for diagnosis and management of cardiac diseases in children.
One of the uses of MRI is tissue characterisation, in which the signal characteristics of the cardiac muscle (myocardium) can be determined with special techniques, known as parametric mapping.
There is increasing evidence that parametric mapping may be able to identify regions of scarring in the myocardium, or detection of oedema/inflammation in the setting. This in turn can help predict disease course and add value to the management of patients.
There is also evidence that other structures that are visualised in parametric mapping aside from the heart (e.g. liver and spleen) can also help improve diagnostic accuracy and guide management.
Currently the majority of studies describing the use of parametric mapping is focused on adults, with limited data on its use in children.
The parametric mapping values can also differ amongst different machines, so calibration with normal subjects are also required.
详细描述
Magnetic resonance Imaging (MRI) can provide tissue characterisation without radiation and need for invasive biopsy.
Parametric mapping techniques (T1 mapping, extracellular volume fraction, T2 mapping, T2* mapping) are methods of quantitative analysis of tissue properties, and are currently commercially available.
T1 mapping, extracellular volume fraction (ECV) and T2* mapping provides knowledge about the tissue properties of the myocardium, interstitium and adjacent structures,and can provide information for diagnosis of fibrosis, inflammatory and infiltrative diseases.
T2 mapping is useful for assessing oedema, which may be useful in monitoring disease activity such as myocarditis.
Parametric mapping has proven clinical utility in iron deposition, amyloid disease, Anderson-Fabry disease and myocarditis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Paediatric patients <=18 years of age with suspected or confirmed cardiac disease undergoing clinically indicated MRI
排除标准
- •Unstable or uncooperative patients that cannot tolerate MRI
- •Patients with contraindications for MRI (e.g. patients with implanted devices that are not MRI compatible)
结局指标
主要结局
Parametric mapping values of normal subjects and patients
时间窗: through study completion, up to 2 years
Parametric mapping values are generated upon completion of the MR sequence
次要结局
未报告次要终点
研究者
Kenneth CHEUNG
Associate Consultant
Hong Kong Children's Hospital