Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing

Not Applicable

Completed

• Conditions: Pacemaker Implantation for Sinus Node Disease

• Registration Number: NCT01803217
• Lead Sponsor: Deutsches Herzzentrum Muenchen

Brief Summary

Unnecessary right ventricular pacing has been shown to be detrimental in recipients of implantable pacemaker or defibrillators.

The ADVANTAGE study evaluates the efficacy of two pacemaker based algorithms (atrioventricular hysteresis function versus mode switch to atrial pacing) to reduce right ventricular pacing.

Detailed Description

Comparison of the effect of an atrioventricular hysteresis function with a mode switch to atrial pacing on the right ventricular pacing percentage in a multi-centre, prospective, randomized, single blinded, cross-over study.

Study Timeline

• Study Start: 2007-11
• Primary Completion: 2011-12
• Study First Submitted: 2013-02-28
• Study First Submitted QC: 2013-03-01
• Study First Posted: 2013-03-04
• Study Completion: 2016-06
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-07
• Last Update Posted: 2017-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Indication for the implantation of a dual-chamber pacemaker

Exclusion Criteria

Persistent or permanent atrial tachyarrhythmias atrioventricular block 2nd or 3rd degree indication or the implantation of an defibrillator

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Right ventricular pacing percentage	3 months

Secondary Outcome Measures

Name	Time	Method
BNP levels	3 months

Trial Locations

Locations (3)

Klinikum Bamberg; 🇩🇪 Bamberg, Bayern, Germany

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen; 🇩🇪 München, Bayern, Germany

Krankenhaus Peißenberg; 🇩🇪 Peißenberg, Bayern, Germany