pilot study of hepatic arterial infusion chemotherapy with cisplatin for advanced hepatocellular carcinoma patients in Child-Pugh score 8,9

Phase 2

• Conditions: advanced hepatocellular carcinoma

• Registration Number: JPRN-UMIN000009272
• Lead Sponsor: Department of Gastroenterology and Metabolism,Hiroshima University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-11-06
• Study Completion: 2017-04-30
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

1) Severe arterio-portal or arterio-venous shunts in the liver 2) Patinets with difficulty with drug arrival to hepatic lesion 3) Other uncontrolled severe illness. a) With severe cardiac failure b) With severe renal function disease c) With active infectious disease except viral hepatitis. d) With active gastrointestinal hemorrhage e) With active other malignancies. f) With hepatic encephalopathy and severe mental disorder g) With clinically significant refractory ascites or pleural effusion 4) Allergic reaction to iodine contrast material, gadolinium contrast material, or platium containing agent. 5) A pregnant woman, or a woman suspected of pregnancy. 6) Patients who are concluded to be inappropriate to participate in this study by their physitians

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
response rate

Secondary Outcome Measures

Name	Time	Method
1) overall survival 2) time to progression 3) safety