Cell SALVage in Obstetrics

Not Applicable

Completed

• Conditions: Haemorrhage / Caesarean Section (CS); Pregnancy and Childbirth; Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified

• Registration Number: ISRCTN66118656
• Lead Sponsor: Queen Mary, University of London (UK)

Brief Summary

2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/29261655 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29318985 2019 results in https://www.ncbi.nlm.nih.gov/pubmed/30782867

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-06-25
• Study Completion: 2016-10-31
• Last Update Posted: 16 March 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 3050

Inclusion Criteria

1. 16 years of age or older
2. Delivery by elective or emergency caesarean section with an identifiable increased risk of haemorrhage
3. Ability to provide informed consent

Exclusion Criteria

1. Elective first Caesarean section for maternal request or breech presentation
2. Sickle cell disease
3. Active malignancy contraindicated to CS e.g. abdominal cancer
4. Cultural or social beliefs contraindicating blood transfusion e.g. Jehovah's Witnesses
5. Significant antibodies making it difficult to find cross matched blood for transfusion
6. Unable to understand written and spoken English

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The proportion of women needing peripartum transfusion. For the IOCS group this is measured by the use of donor blood transfusion; transfusion of routinely salvaged blood as part of the intervention will not count as an event. For the standard care group this is measured by the use of donor blood transfusion and/or the use of salvaged blood transfusion set up as an emergency to deal with haemorrhage.