NCT05195983尚未招募不适用
Hemodynamic Changes in Acute Ischaemic Stroke Patients Receiving Intravenous Thrombolysis.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- Clinical outcomes 1-neurological outcomes
研究概览
简要总结
- To assess Hemodynamic changes in rtPA receiving Acute Ischaemic Stroke patients.
- To assess the efficacy of rtPA in treatment of Acute Ischaemic Stroke patients.
- To correlate TCD findings (post treatment) with one of standard vascular imaging in AIS (CTA or MRA).
详细描述
- Stroke is a major healthcare issue worldwide representing the third most common cause of death in the United Kingdom. Approximately 50% of cerebrovascular events were in those aged under 75 years despite previous indications that stroke was more a disease of the elderly population. Stroke can be considered to represent a greater healthcare burden than acute coronary disease resulting from residual disability. A greater understanding of the underlying cause of stroke and subsequent mortality will be required to establish appropriate prevention and treatment strategies.
1 - Laboratory:
- The relationship between the neutrophil-to-lymphocyte ratio (NLR) and poor prognostics in acute ischemic stroke (AIS) patients who receive intravenous thrombolysis (IVT) remains controversial. We aimed to determine whether the NLR at admission or post IVT plays a role in AIS patients who received IVT. Fibrin degradation products (FDPs), which can compete with fibrinogen for binding to the platelet membrane and thus interfere with platelet aggregation, are fragments released by the plasmin-mediated degradation of fibrinogen or fibrin. The FDPs level is very sensitive to intravascular thrombus and maybe markedly elevated one the coagulation and fibrinolytic system is activated.
2- Radiological:
- Transcranial Doppler ultrasound (TCD) role in detecting acute intracranial artery occlusions is well known. The technique has 94% specificity and 79% sensitivity compared with computerized tomographic angiography (CTA) in acute cerebral ischemia. TCD can provide useful information such as state of collateral flow through the ophthalmic artery and circle of Willis, emboli detection, and real-time bedside monitoring of acute intracranial occlusions. Also, it is useful in selecting patients for bridging therapy after unsuccessful intravenous thrombolysis (IVT).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18, both sexes, acute ischemic stroke within 4.5 hours, NIHSS (5-25)
排除标准
- •Significant head trauma or prior stroke in the previous 3 months
- •Symptoms suggest subarachnoid hemorrhage
- •Arterial puncture at a noncompressible site in previous 7 days
- •History of previous intracranial hemorrhage
- •Intracranial neoplasm, AVM, or an aneurysm
- •Recent intracranial or intraspinal surgery
- •Elevated blood pressure (systolic greater than 185 mmHg or diastolic greater than 110 mmHg)
- •Active internal bleeding
- •Acute bleeding diathesis, including but not limited to
- •Platelet count less than 100 000/mm^3
- •Heparin received within 48 hours resulting in abnormally elevated aPTT above the upper limit of normal
- •Current use of anticoagulant with INR greater than 1.7 or PT greater than 15 seconds
- •Current use of direct thrombin inhibitors or direct factor Xa inhibitors with elevated sensitive laboratory tests (e.g., aPTT, INR, platelet count, ECT, TT, or appropriate factor Xa activity assays)
- •Blood glucose concentration less than 50 mg/dL (2.7 mmol/L)
- •CT demonstrates multilobar infarction (hypodensity greater than a one-third cerebral hemisphere) Relative Exclusion Criteria
- •Recent experience suggests that under some circumstances, with careful consideration and weighing of risk to benefit, patients may receive fibrinolytic therapy despite 1 or more relative contraindications. Consider the risk to the benefit of intravenous rtPA administration carefully if any of these relative contraindications are present:
- •Only minor or quickly improving stroke symptoms (clearing automatically)
- •Pregnancy
- •Seizure at the onset with postictal residual neurological impairments
- •Major surgery or serious trauma within prior 14 days
- •Recent GI or urinary tract hemorrhage (within previous 21 days)
结局指标
主要结局
Clinical outcomes 1-neurological outcomes
时间窗: 7 days
assessed by NIHSS and comprising improvement (reduction of 10 points or final NIHSS ≤3) or deterioration (increase ≥4 points) in the early post-thrombolytic therapy stage
2-functional
时间窗: baseline
defined by modified Rankin scale (mRS) in the late post-thrombolytic therapy (2-3 months) with good outcome been considered as mRS ≤2 ,with sICH is defined as rtPA-related intracerebral bleeding detected by CT or MRI associated with any worsening of NIHSS or death.
次要结局
- Radiological outcome(24 hours)
- laboratory outcome(baseline)
研究者
Mustafa Ahmed Sedky Abdallah
resident
Assiut University
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