Carbetocin Versus Combined Oxytocin and Misoprostol for Prevention of Postpartum Hemorrhage in Women With Severe Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- The rate of postpartum hemorrhage more than 1000 ml
研究概览
简要总结
The study compares the effect of Intravenous carbetocin versus combined use of intravenous oxytocin and rectal misoprostol for prevention of postpartum hemorrhage during delivery of women with severe preeclampsia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant women which diagnosed with severe pre-eclampsia.
- •Singleton pregnancy.
- •Termination of pregnancy by Cesarean section after 28 weeks of gestation.
排除标准
- •Suspected or proven placental abruption.
- •Known placenta Previa or acreata.
- •Multiple pregnancies.
- •Obesity (BMI >35).
- •Anemia (<9 g/dl).
- •Retained placental tissues.
- •Big baby (> 4 kg).
- •Presence of coagulopathy.
- •Polyhydramnios.
- •Presence of Uterine fibroids.
- •Medical diseases as; cardiac, liver, renal or endocrine diseases.
- •General anesthesia.
研究组 & 干预措施
Oxytocin plus misoprostol
Patient received 10 units of oxytocin IV drip and 400 mcg of misoprostol rectally after anesthesia.
干预措施: Misoprostol (Drug)
Carbetocin
Patient received 100 mcg of carbetocin intravenous over one minute immediately after delivery of the baby.
干预措施: Carbetocin (Drug)
Oxytocin plus misoprostol
Patient received 10 units of oxytocin IV drip and 400 mcg of misoprostol rectally after anesthesia.
干预措施: Oxytocin (Drug)
结局指标
主要结局
The rate of postpartum hemorrhage more than 1000 ml
时间窗: 30 minutes
the amount of bleeding during and after CS
次要结局
未报告次要终点
研究者
Ahmed Mohamed Abbas
Principal investigator
Assiut University