The effects of a cognition enhancer (CILTEP) on a cognitive test battery and EEG in middle-aged and old volunteers

Completed

Conditions: geen aandoening
nvt

Registration Number: NL-OMON47611

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 91

Inclusion Criteria

30-40 or 60-75 years of age
Healthy
Normal static binocular acuity (corrected or uncorrected)
Body mass index between 18.5-30
Score op de Woord-Leertaak die binnen 1 standaarddeviatie van het gemiddelde valt
Willingness to sign informed consent

Exclusion Criteria

having a history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, having a first-degree relative with a psychiatric disorder or a history with a psychiatric disorder, excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of psychoactive medication, centrally acting beta blockers, use of recreational drugs from 2 weeks before until the end of the experiment, systolic blood pressure above 160 mmHg, phenylketonuria, any sensory or motor deficits which could reasonably be expected to affect test performance, and use of steroids or Sudafed (pseudoephedrine).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure is the number of recalled words in a verbal word lea<br /><br>rning task, and the score on a spatial memory task which measures how<br /><br>efficiently subjects can separate a representation of a picture from a similar,<br /><br>but different, picture.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The following secundary measures will be examined in this study:<br /><br><br /><br>* The number of words memorized long-term in a verbal learning task.<br /><br>* The number of correct responses in a working memory task.<br /><br>* The performance on the Digit symbol substitution task to assess complex scanni<br /><br>ng.<br /><br>* The speed of responding in combination with correct responses in a psychomotor<br /><br> task.<br /><br>The performance on a trail making test which measures mental flexibility and<br /><br>attention.<br /><br> The performance on the Stroop to measure attention and inhibition.<br /><br>* EEG measurement during the above mentioned behavioral tasks and during a<br /><br>sensory gating task, which look at the efficiency of the brain in filtering out<br /><br>unnecessary information.</p><br>