An open label prospective clinical study of a protocol-based Ayurvedic intervention in male infertility due to Oligospermia
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Volume
研究概览
简要总结
Infertility is a problem of global proportions, affecting on an average 8-12% couples worldwide. Male infertility is considerably less complicated than Female infertility, but account for 30-40% of infertility. Except for some physical defects, low sperm count &poor sperm quality are responsible for male infertility in more than 90% cases. Oligozoospermia (sperm count < 20 million /ml semen),in about 30-40% the cause is unexplained, and in the rest of the cases critical illness, malnutrition, genetic abnormalities, pollution, side effects of some medicines, hormones and chemicals play a major role Oligozoospermic conditions can be correlated to that of kshina shukra concepts in ayurveda. The pathogenesis of kshina shukra is not mentioned in the classics, but it is stated that the vitiation of vata and pitta dosha is responsible for the manifestation of kshina shukra. Sub- normal parameters of shukra includes dravya,guna,karma features of shukra.The main line of treatment of kshina shukra has been suggested to be’ kshine shukrakarikriya’ and upachaya is the primary line of treatment. Drugs having vrishya, rasayana, and vajikarana properties can provide better results in the management of kshina shukra. A protocol incorporated with rookshana,snehana,swedana(poorvakarma) virechana and vasti with shukra shodhana gana kwatham, will be capable of relieving symptoms of Ksheena shukra. After shodhana karma, internal medication for Vajikarana, which can bring a markable change in Oligospermia cases.
Shodhana chikitsa followed by Samana chikitsa will be adopted
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)(—)
- 性别
- Male
入选标准
- •Male subjects of Age group between 20-45 years
- •Sperm count less than 15million /ml.
- •Diagnosed cases of oligospermia
- •Subjects fit for Shodhana
- •Both fresh and treated cases will be included.
排除标准
- •Varicocele with surgical indication
- •Sexually Transmitted Disease
- •Subjects categorized under Azoospermia.
- •Tuberculosis, HIV, AIDS, CA Testis.
结局指标
主要结局
Volume
时间窗: Base line 0th day | fourth week | eighth week
pH
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Morphology
时间窗: Base line 0th day | fourth week | eighth week
Liquefaction time
时间窗: Base line 0th day | fourth week | eighth week
Sperm concentration
时间窗: Base line 0th day | fourth week | eighth week
次要结局
未报告次要终点
研究者
K Parameswaran Namboothiri
Amrita School Of Ayurveda, Amritapuri, Amrita vishwa vidyapeetham, India
