Effect of Metoclopramide Versus Erythromycin on on Gastric Residual Volume
- Conditions
- Gastric Residual Volume
- Interventions
- Registration Number
- NCT04682691
- Lead Sponsor
- Cairo University
- Brief Summary
In emergencies, it may be necessary to anaesthetize who are not fully starved and consequently at risk of pulmonary aspiration. Pregnancy are recognized to be at increased risk of aspiration compared with non-pregnancy. Prokinetic agents such as metoclopramide can be used to reduce GRV. Metoclopramide is widely used as a prokinetic agent in adults and is licensed for premedication in pregnancy, but its use may be limited by its potential for producing extrapyramidal side effects. Erythromycin is an effective prokinetic agent in adults but there is no work examining its use for premedication in pregnancy. This study compared the effects of erythromycin and metoclopramide on GRV in full-term pregnant women
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 50
-
Non-laboring pregnant women ≥36 weeks gestational age
-
Parturient scheduled for elective caesarian delivery.
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Singleton pregnancy
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Age greater than 18 years
-
Having followed institutional fasting guidelines (a minimum of 2 h for clear fluids, 6 h for a light meal, and 8 h for a meal that included fried or fatty food)
- Exclusion criteria:
-
Refusal of the patient
-
Deviation from fasting times
-
Patients with empty stomach
-
Emergency operation
-
Body mass index (BMI) greater than 40 kg/m2
-
American Society of Anesthesiologists (ASA) physical status class III, IV.
-
Gestational diabetes mellitus
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Multiple gestations
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Patients with polyhydramnios liquor.
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Preeclampsia patients
-
Chronic kidney disease patients
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Systemic diseases may cause delayed gastric emptying (eg: myopathies and myasthenia gravis).
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Patients with gastrointestinal diseases such as hiatus hernia, intestinal disease and gastro-oesophageal reflux disease and patients with history of upper gastrointestinal surgeries.
-
Patients on antidepressants and monoamine oxidase inhibitors
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Use of other medications known to affect gastric motility or secretions.
-
Allergy to macrolide or metoclopramide
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group (C) naturally flavored water will be receive flavored water in total volume 15 ml Group (M) metoclopramide (10mg) will be receive 10 ml of oral metoclopramide (10mg) + 5 ml of flavored water in total volume 15 ml Group (E) Erythromycin (400mg) will be receive 10 ml of oral Erythromycin (400mg) + 5 ml of flavored water in total volume 15 ml
- Primary Outcome Measures
Name Time Method Estimated Gastric volume UP TO 6 HOURE (ml/kg) after a six-hour fast using Roukhomovsky's equation after administration of the study drug.
- Secondary Outcome Measures
Name Time Method quantitative gastric contents up to 24 hours every one hours estimated GV till ( \< 1.5 ml/kg) post-drug administration
low-risk stomach six hours after drug administration up to 6 hours number of patient and %
Perlas grading system UP TO 24 HOURE Grade 0 antrum: absent fluid content in both supine and RLD positions Grade 1 antrum: fluid is observed only in the RLD position, but not in the supine position Grade 2 antrum: fluid is observed in both supine and RLD
Evaluation of the risk of aspiration UP TO 24 HOURE residual gastric volume \< 1.5 mL/kg
Trial Locations
- Locations (1)
Faculty of Medicine, Cairo University.
🇪🇬Cairo, Egypt