The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Not Applicable

• Conditions: Chronic Cough
• Interventions: Other: capsaicin challenge

• Registration Number: NCT01807832
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Detailed Description

Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Study Timeline

• Status Verified: 2013-03
• Study Start: 2013-03
• Study First Submitted: 2013-03-07
• Study First Submitted QC: 2013-03-07
• Last Update Submitted: 2013-03-07
• Study First Posted: 2013-03-08
• Last Update Posted: 2013-03-08
• Primary Completion: 2013-12
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion Criteria

• Diagnosis of respiratory or lung diseases of any kind

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
chronic cough	capsaicin challenge	Capsaicine challenge in chronic cough patients

Primary Outcome Measures

Name	Time	Method
cough reflex hypersensitivity	3 months