Difference of PTEN / PI3K / Akt signaling pathway between colorectal damp heat syndrome and spleen stomach weakness syndrome in patients with colon adenoma

Phase 1

• Conditions: Adenoma of colon

• Registration Number: ITMCTR2000004106
• Lead Sponsor: Shanghai Traditional Chinese MedicineIntegrated Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. according to the diagnosis of colon adenoma: according to the jnet classification of 2A under endoscopy, the pathological diagnosis was in accordance with low-grade intraepithelial neoplasia of adenoma;
2. TCM syndrome differentiation was consistent with large intestine damp heat syndrome or spleen and stomach weakness syndrome;
3. aged 18-75 years old;
4. signed informed consent and voluntarily entered the trial.
Large intestine dampness heat syndrome: main symptoms:
(1) stool frequency increased, diarrhea is more smelly, or pus blood, or such as water injection;
(2) there are urgent afterweight, anus burning;
(3) red tongue, yellow or yellow greasy or yellow dry.
Secondary symptoms:
(1) abdominal pain refused to press, fullness and discomfort;
(2) Fanke drink or do not want to drink;
(3) constipation or loose stool;
(4) hot and sweating;
(5) short red urine;
(6) head and body weight;
(7) pulse slip number.
Syndrome determination: 2 main symptoms + 3 secondary symptoms, Spleen and stomach deficiency syndrome: main symptoms:
(1) abdominal distension, less intake, after eating, bloating;
(2) loose and thin stool;
(3) mental fatigue and fatigue;
(4) shortness of breath and lazy speech;
(5) light tongue, thin and white fur.
Secondary symptoms:
(1) continuous abdominal pain, from time to time, like warming and pressing;
(2) cold shape and cold limbs;
(3) no Chinese complexion;
(4) poor appetite;
(5) loose stool;
(6) fat tongue;
(7) fine pulse.
Syndrome determination: 2 main symptoms + 3 secondary symptoms

Exclusion Criteria

(1) patients under 18 years old or over 75 years old, pregnant and lactating women;
(2) pathological diagnosis of non adenomatous low-grade intraepithelial neoplasia;
(3) colonoscopy contraindications or other reasons can not be performed colonoscopy;
(4) enteroscopy diagnosis of enteritis, intestinal ulcer, non intestinal polyps;
(5) digestive tract tumors;
(6) Combined with cardiovascular and cerebrovascular, liver and kidney, blood system and other serious primary diseases, mental patients;
(7) syndrome differentiation of traditional Chinese medicine has concurrent syndrome.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
AKT Protein;PTEN Protein;PI3K Protein;