Prebiotic Effects of a Polyphenol-rich Food Product
Not Applicable
Completed
- Conditions
- Dysbiosis
- Registration Number
- NCT03659240
- Lead Sponsor
- Iowa State University
- Brief Summary
The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- BMI 27-35 kg/m2
- High waist circumference (men >102 cm and women >88 cm)
Exclusion Criteria
- Cigarette smoking
- Regular intensive exercise
- Pregnancy or lactation
- Chronic diarrhea, constipation, or other gastrointestinal complaint
- Diabetes mellitus, autoimmune disease, or other chronic disease known to alter the gut microbiota
- Use of medications that affect inflammation or the gut microbiota
- Use of prebiotics, probiotics, synbiotics, vitamins, or other dietary supplements known to affect the gut microbiota
- Aversion to cranberries
- Food allergies
- Lactose intolerance
- Vegetarianism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Fecal microbial community composition and structure Changes in the fecal microbiota will be measured after a 20-day intervention period We will investigate if specific bacterial taxa are stimulated by daily consumption of a cranberry beverage.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Nutrition and Wellness Research Center
🇺🇸Ames, Iowa, United States
Nutrition and Wellness Research Center🇺🇸Ames, Iowa, United States