Effect of early adminestration of corton in sepsis
Phase 3
Recruiting
- Conditions
- sepsis.Systemic Inflammatory Response Syndrome of infectious origin with organ failureSevere sepsisR65.1
- Registration Number
- IRCT20230701058635N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Age of 18–89 years
Systolic blood pressure of <90 mmHg or plasma lactate level of >2 mmol/L
SOFA score of =2 points consequent to the infection
Exclusion Criteria
Rejection of sepsis diagnosis after initial evaluations
Decision to limit or withdraw treatment
Steroid use within 4 weeks
Chemotherapy for underlying malignancy within 4 weeks
Etomidate use during hospitalization
Pregnancy or lactation
Informed written consent cannot be obtained from a patient or legal representative
Corticosteroides contraindications
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to enter the septic shock. Timepoint: Every 1-hour. Method of measurement: According mean artrial pressure.
- Secondary Outcome Measures
Name Time Method Vasopressor requirement. Timepoint: Every 1-hour. Method of measurement: Starting a vasopressor drug (type and dose).;Need for mechanical ventilation support. Timepoint: Every 1-hour. Method of measurement: Patient intubation.;7-day mortality. Timepoint: 7 days after initial treatment. Method of measurement: patient follow-up.;28-day mortality. Timepoint: 28 days after initial treatment. Method of measurement: patient follow-up.;Length of stay in ICU. Timepoint: Daily. Method of measurement: patient follow-up.