A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Phase 3

Active, not recruiting

• Conditions: Multiple Sclerosis
• Interventions: Drug: Ocrelizumab

• Registration Number: NCT05269004
• Lead Sponsor: Hoffmann-La Roche

Brief Summary

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-02-11
• Study First Submitted QC: 2022-03-04
• Study First Posted: 2022-03-07
• Study Start: 2022-05-03
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-13
• Last Update Posted: 2025-03-17
• Primary Completion: 2029-12-31
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1300

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Ocrelizumab	Ocrelizumab	Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046). Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.

Primary Outcome Measures

Name	Time	Method
Incidence and severity of adverse events, with severity determined according to the NCI CTCAE v5.0	Up to 44 months

Secondary Outcome Measures

Name	Time	Method
The change in total volume of T2 lesions and in total non-enhancing T1 lesion volume	Week 0, 24, 48, 72, 96, 120, 168
Change in 9-Hole Peg Test (9HPT) over time	Week 0, 24, 48, 72, 96, 120, 168
The number of T1 lesions and number of new or enlarging T2 lesions	Week 0, 24, 48, 72, 96, 120, 168
Change in Timed 25-Foot Walk Test (T25FWT) over time	Week 0, 24, 48, 72, 96, 120, 168
Change in Expanded Disability Status Scale (EDSS) score over time	Week 0, 24, 48, 72, 96, 120, 168

Trial Locations

Locations (234)

Krajska zdravotni a.s. - Nemocnice Teplice o.z.; 🇨🇿 Teplice, Czechia

West Tallinn Central Hospital; 🇪🇪 Tallinn, Estonia

Tartu University Hospital; 🇪🇪 Tartu, Estonia

Tammer Tutka Oy; 🇫🇮 Tampere, Finland

CHU CAEN - Hôpital de la Côte de Nacre; 🇫🇷 Caen Cedex 9, Calvados, France

Groupe Hospitalier Pellegrin; 🇫🇷 Bordeaux, France

Hopital Neurologique Pierre Wertheimer; 🇫🇷 Bron, France

CHU Hopital Gabriel Montpied; 🇫🇷 Clermont Ferrand Cedex, France

Hopital Roger Salengro Service de Neurologie; 🇫🇷 Lille, France

CHU Nancy Hôpital Central; 🇫🇷 Nancy, France

CHU Nice - Hôpital Pasteur 2; 🇫🇷 Nice Cedex 1, France

Centre Hospitalier Intercommunal de Poissy; 🇫🇷 Poissy, France

CHU Strasbourg Hôpital Hautepierre; 🇫🇷 Strasbourg, France

Klinikum Bayreuth Standort Hohe Warte Klinik fur Neurologie; 🇩🇪 Bayreuth, Germany

Charité Universitaetsmedizin Berlin - Campus Ch; 🇩🇪 Berlin, Germany

Jüdisches Krankenhaus Berlin; 🇩🇪 Berlin, Germany

Neurologie in Bonn; 🇩🇪 Bonn, Germany

Universitaetsklinikum Carl Gustav Carus TU Dresden; 🇩🇪 Dresden, Germany

Fondazione Istituto G. Giglio di Cefalu; 🇮🇹 Cefalù, Sicilia, Italy

Azienda Socio Sanitaria Territoriale della Valle Olona (pres; 🇮🇹 Gallarate, Valle D?Aosta, Italy

Maritime Medicine Centre of Latvia Hospital of Vecmilgravis Department of Neurology; 🇱🇻 Riga, Latvia

Pauls Stradins Clinical University Hospital; 🇱🇻 Riga, Latvia

Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria; 🇵🇹 Lisboa, Portugal

Hospital Garcia de Orta; 🇵🇹 Pragal, Portugal

Spitalul Universitar de Urgenta Elias; 🇷🇴 Bucuresti, Romania

SC Clubul Sanatatii SRL; 🇷🇴 Campulung, Romania

Siberian Medical Center; 🇷🇺 Barnaul, Altaj, Russian Federation

Pardubicka krajska nemocnice a.s.; 🇨🇿 Pardubice, Czechia

Vseobecna fakultni nemocnice v Praze; 🇨🇿 Praha 2, Czechia

Fakultni nemocnice Hradec Kralove; 🇨🇿 Hradec Kralove, Czechia

Nemocnice Jihlava; 🇨🇿 Jihlava, Czechia

OnSite Clinical Solutions LLC; 🇺🇸 Charlotte, North Carolina, United States

The Neurological Institute PA; 🇺🇸 Charlotte, North Carolina, United States

State Institution Minsk Research and Practice Center of Surgery Transplantation and Hematology; 🇧🇾 Minsk, Belarus

Barrow Neurological Institute; 🇺🇸 Phoenix, Arizona, United States

Arizona Neuroscience Research LLC; 🇺🇸 Phoenix, Arizona, United States

MS Center of California; 🇺🇸 Laguna Hills, California, United States

Stanford Hospital and Clinics; 🇺🇸 Palo Alto, California, United States

University of California San Francisco; 🇺🇸 San Francisco, California, United States

AZ Sint Jan; 🇧🇪 Brugge, Belgium

University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center); 🇺🇸 Aurora, Colorado, United States

Advanced Neurosciences Research LLC; 🇺🇸 Fort Collins, Colorado, United States

Neurology Associates PA; 🇺🇸 Maitland, Florida, United States

University of Miami; 🇺🇸 Miami, Florida, United States

Neurological Services of Orlando; 🇺🇸 Orlando, Florida, United States

University of South Florida; 🇺🇸 Tampa, Florida, United States

Vero Beach Neurology and Research Institute; 🇺🇸 Vero Beach, Florida, United States

Atlanta Neuroscience Institute; 🇺🇸 Atlanta, Georgia, United States

Northwestern University; 🇺🇸 Chicago, Illinois, United States

Consultants in Neurology Ltd; 🇺🇸 Northbrook, Illinois, United States

Indiana Univ School of Med; 🇺🇸 Indianapolis, Indiana, United States

Kansas University Medical Center; 🇺🇸 Kansas City, Kansas, United States

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States

Wayne State University; 🇺🇸 Detroit, Michigan, United States

Michigan Institute for Neurological Disorders; 🇺🇸 Farmington Hills, Michigan, United States

Henry Ford Hospital; 🇺🇸 West Bloomfield, Michigan, United States

Minneapolis Clinic of Neurology; 🇺🇸 Golden Valley, Minnesota, United States

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States

Washington University; 🇺🇸 Saint Louis, Missouri, United States

University of Nebraska Medical Center; 🇺🇸 Omaha, Nebraska, United States

Rutgers New Jersey Medical School Department of Neurology; 🇺🇸 Newark, New Jersey, United States

Holy Name Hospital; 🇺🇸 Teaneck, New Jersey, United States

University of New Mexico; 🇺🇸 Albuquerque, New Mexico, United States

South Shore Neurologic Associates PC; 🇺🇸 Patchogue, New York, United States

SUNY at Stony Brook; 🇺🇸 Stony Brook, New York, United States

Atrium Health; 🇺🇸 Charlotte, North Carolina, United States

Raleigh Neurology Associates; 🇺🇸 Raleigh, North Carolina, United States

University Neurology Inc.; 🇺🇸 Cincinnati, Ohio, United States

Columbus Neuroscience; 🇺🇸 Westerville, Ohio, United States

Oklahoma Medical Research Foundation; 🇺🇸 Oklahoma City, Oklahoma, United States

Providence Neurological Specialties; 🇺🇸 Portland, Oregon, United States

Abington Neurological Associates; 🇺🇸 Abington, Pennsylvania, United States

Rhode Island Hospital; 🇺🇸 Providence, Rhode Island, United States

Neurology Clinic PC; 🇺🇸 Cordova, Tennessee, United States

Sibyl Wray MD Neurology PC; 🇺🇸 Knoxville, Tennessee, United States

Baylor College of Medicine; 🇺🇸 Houston, Texas, United States

Uni of Texas Health Science Center At Houston; 🇺🇸 Houston, Texas, United States

Bhupesh Dihenia M.D. P.A.; 🇺🇸 Lubbock, Texas, United States

Neurology Center of San Antonio; 🇺🇸 San Antonio, Texas, United States

University of Vermont Medical Center; 🇺🇸 Burlington, Vermont, United States

Swedish Neuroscience Institute; 🇺🇸 Seattle, Washington, United States

MultiCare Health System Institute for Research and Innovation; 🇺🇸 Tacoma, Washington, United States

Hospital Español; 🇦🇷 Ciudad Autonoma Bs As, Argentina

Fundacion Rosarina de Neurorehabilitacion; 🇦🇷 Rosario, Argentina

Royal North Shore Hospital; 🇦🇺 St Leonards, New South Wales, Australia

St Vincent's Hospital Melbourne; 🇦🇺 Fitzroy, Victoria, Australia

Medizinische Universität Innsbruck; 🇦🇹 Innsbruck, Austria

Barmherzige Brueder Konventspital; 🇦🇹 Linz, Austria

AKH - Medizinische Universität Wien; 🇦🇹 Wien, Austria

Grodno University Hospital; 🇧🇾 Grodno, Brestskaya Voblasts', Belarus

Vitebsk Regional Clinical Hospital; 🇧🇾 Vitebsk, Vitsyebskaya Voblasts', Belarus

Cliniques Universitaires Saint-Luc; 🇧🇪 Bruxelles, Belgium

UZA; 🇧🇪 Edegem, Belgium

Algemeen Ziekenhuis Alma; 🇧🇪 Eeklo, Belgium

AZ Delta Campus Westlaan; 🇧🇪 Roeselare, Belgium

HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás; 🇧🇷 Goiania, Goiás, Brazil

IMV Pesquisa Neurologica Sociedade Simples Ltda; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Hospital Sao Lucas da PUCRS*X; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Clinica Neurológica e Neurocirúrgica de Joinville; 🇧🇷 Joinville, Santa Catarina, Brazil

Hospital Universitario Gaffree e Guinle; 🇧🇷 Rio de Janeiro, Brazil

HUCFF-UFRJ - Hospital Universitário Clementino Fraga Filho Universidade Federal do Rio de Janeiro; 🇧🇷 Rio de Janeiro, Brazil

MHAT Avis Medica OOD Department of Neurology; 🇧🇬 Pleven, Bulgaria

MHATNP Sveti Naum EAD; 🇧🇬 Sofia, Bulgaria

University First MHAT-Sofia St. Joan Krastitel EAD; 🇧🇬 Sofia, Bulgaria

National Heart Hospital EAD; 🇧🇬 Sofia, Bulgaria

Acibadem City Clinic Tokuda Hospital Ead; 🇧🇬 Sofia, Bulgaria

Military Medical Academy MHAT Sofia Department of Rheumatology; 🇧🇬 Sofia, Bulgaria

Calgary MS Clinic; 🇨🇦 Calgary, Alberta, Canada

University of Alberta; 🇨🇦 Edmonton, Alberta, Canada

UBC Multiple Sclerosis & Neuromyelitis Optica NMO Clinical Trials; 🇨🇦 Vancouver, British Columbia, Canada

The Ottawa Hospital - General Campus; 🇨🇦 Ottawa, Ontario, Canada

St Michael Hospital; 🇨🇦 Toronto, Ontario, Canada

Clinique Neuro Outaouais; 🇨🇦 Gatineau, Quebec, Canada

Recherche Sepmus Inc.; 🇨🇦 Greenfield Park, Quebec, Canada

Montreal Neurological Institute and Hospital; 🇨🇦 Montreal, Quebec, Canada

General Hospital Varazdin; 🇭🇷 Varazdin, Croatia

University Hospital Center Zagreb; 🇭🇷 Zagreb, Croatia

Fakultni nemocnice Brno; 🇨🇿 Brno, Czechia

Fakultni nemocnice u sv. Anny v Brne; 🇨🇿 Brno, Czechia

Neurospol s.r.o.; 🇨🇿 Havirov, Czechia

Universitaetsklinikum Duesseldorf; 🇩🇪 Düsseldorf, Germany

Zentrum fuer ambulante Neurologie; 🇩🇪 Essen, Germany

Klinikum der Johann Wolfgang Goethe-Universitaet; 🇩🇪 Frankfurt, Germany

Universitaetsklinikum Giessen und Marburg GmbH; 🇩🇪 Gießen, Germany

Universitaetsklinikum Leipzig; 🇩🇪 Leipzig, Germany

Pharmakologisches Studienzentrum; 🇩🇪 Mittweida, Germany

Universitaetsklinikum Muenster; 🇩🇪 Muenster, Germany

Klinikum rechts der Isar der TU Muenchen; 🇩🇪 München, Germany

Medizinische Einrichtungen des Bezirks Oberpfalz GmbH; 🇩🇪 Regensburg, Germany

Universitaetsklinikum Tuebingen; 🇩🇪 Tübingen, Germany

Universitätsklinikum Ulm; 🇩🇪 Ulm, Germany

Studienzentrum Nordwest Dr med Joachim Springub Herr Wolfgang Schwarz; 🇩🇪 Westerstede, Germany

S-Medicon Egeszsegugyi Szolgaltato Kft.; 🇭🇺 Budapest, Hungary

Jahn Ferenc Del-Pesti Korhaz es Rendelointezet; 🇭🇺 Budapest, Hungary

Pecsi Tudomanyegyetem; 🇭🇺 Pecs, Hungary

Hadassah University Hospital - Ein Kerem; 🇮🇱 Jerusalem, Israel

Rabin Medical Center Beilinson Campus; 🇮🇱 Petach Tikva, Israel

Chaim Sheba Medical Center; 🇮🇱 Ramat Gan, Israel

Tel Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel

Ospedale degli Infermi; 🇮🇹 Ponderano, Friuli-Venezia Giulia, Italy

Azienda Ospedaliera Universitaria Policlinico Tor Vergata; 🇮🇹 Roma, Lazio, Italy

Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien; 🇮🇹 Roma, Lazio, Italy

Ospedale Policlinico San Martino; 🇮🇹 Genova, Liguria, Italy

Hospital San Raffaele; 🇮🇹 Milano, Lombardia, Italy

Fondazione IRCCS Istituto Neurologico Carlo Besta; 🇮🇹 Milano, Lombardia, Italy

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili); 🇮🇹 Montichiari, Lombardia, Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti; 🇮🇹 Torrette Di Ancona, Marche, Italy

Azienda Sanitaria Ospedaliera S Luigi Gonzaga; 🇮🇹 Orbassano, Piemonte, Italy

Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution; 🇱🇹 Kaunas, Lithuania

Klaipeda University Hospital Public Institution; 🇱🇹 Klaipeda, Lithuania

Vilnius University Hospital Santaros Klinikos; 🇱🇹 Vilnius, Lithuania

Mexico Centre for Clinical Research; 🇲🇽 Ciudad de México, Mexico CITY (federal District), Mexico

Hospital Mexico Americano; 🇲🇽 Guadalajara, Mexico CITY (federal District), Mexico

Clinical Research Institute; 🇲🇽 Tlalnepantla de Baz, Mexico CITY (federal District), Mexico

Hospital Universitario Dr Jose Eleuterio Gonzalez; 🇲🇽 Monterrey, Nuevo LEON, Mexico

Centro de Estudios Clinicos y Especialidades Medicas S C; 🇲🇽 Monterrey, Nuevo LEON, Mexico

Hospital Angeles Culiacan; 🇲🇽 Culiacan, Sinaloa, Mexico

Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. Aguascalientes; 🇲🇽 Aguascalientes, Mexico

Hospital Angeles Chihuahua; 🇲🇽 Chihuahua, Mexico

Grupo Medico Camino; 🇲🇽 Mexico, Mexico

Zuyderland Medisch Centrum - Sittard-Geleen'; 🇳🇱 Sittard-Geleen, Netherlands

Waikato Hospital; 🇳🇿 Hamilton, New Zealand

Haukeland Universitetssykehus; 🇳🇴 Bergen, Norway

NZOZ Vitamed; 🇵🇱 Bydgoszcz, Poland

COPERNICUS Podmiot Leczniczy Sp z o o; 🇵🇱 Gda?sk, Poland

M.A. LEK A.M.Maciejowscy SC.; 🇵🇱 Katowice, Poland

Specjal. Praktyka Lekarska; 🇵🇱 Katowice, Poland

Neuro-Medic Janusz Zbrojkiewicz; 🇵🇱 Katowice, Poland

Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K; 🇵🇱 Krakow, Poland

Centrum Neurologii Krzysztof Selmaj; 🇵🇱 Lodz, Poland

Uniwersytecki Szpital Kliniczny nr 4 w Lublinie; 🇵🇱 Lublin, Poland

Wojewodzki Specjalistyczny Szpital w Olsztynie; 🇵🇱 Olsztyn, Poland

Neurologiczny NZOZ Centrum Leczenia SM; 🇵🇱 Plewiska, Poland

Neuro-Care Gabriela Klodowska; 🇵🇱 Siemianowice ?l?skie, Poland

Centrum Medyczne NeuroProtect; 🇵🇱 Warszawa, Poland

Hospital de Braga; 🇵🇹 Braga, Portugal

Centro Hospitalar E Universitário de Coimbra EPE; 🇵🇹 Coimbra, Portugal

SBIH of Republic Mordoviya "Republican Clinical Hospital # 4"; 🇷🇺 Saransk, Mordovija, Russian Federation

FGBU FNKC FMBA of Russia; 🇷🇺 Moskva, Moskovskaja Oblast, Russian Federation

SBIH City Polyclinic 2 of the Department of Health of the City of Moscow; 🇷🇺 Moskva, Moskovskaja Oblast, Russian Federation

FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov" of the MoD of the RF; 🇷🇺 Sankt-peterburg, Sankt Petersburg, Russian Federation

SPb SBIH "City Multy-field Hospital # 2"; 🇷🇺 Sankt-peterburg, Sankt Petersburg, Russian Federation

Pavlov First Saint Petersburg State Medical University; 🇷🇺 St. Petersburg, Sankt Petersburg, Russian Federation

SBIH of Stavropol territory " City Hospital # 2" of Pyatigorsk; 🇷🇺 Pyatigorsk, Stavropol, Russian Federation

Sverdlovsk Regional Clinical Hospital 1; 🇷🇺 Yekaterinburg, Sverdlovsk, Russian Federation

Regional Multiple Sclerosis Centre b/o CC ECM Neftyanik; 🇷🇺 Tyumen, Tjumen, Russian Federation

SAHI "Interregional Clinical and Diagnostic Center"; 🇷🇺 Kazan, Vologda, Russian Federation

Perm SMA n.a. academ. E.A. Vagner; 🇷🇺 Perm, Vologda, Russian Federation

SAIH "Kemerovo Regional Clinical Hospital"; 🇷🇺 Kemerovo, Russian Federation

Kirov RSBIH "Kirov City Clinical Hospital # 1"; 🇷🇺 Kirov, Russian Federation

FSBIH Siberian Clinical Center of FMBA of Novosibirsk; 🇷🇺 Novosibirsk, Russian Federation

SBEI HPE "Samara State Medical University" of the MoH of the RF; 🇷🇺 Samara, Russian Federation

Saratov State Medical University; 🇷🇺 Saratov, Russian Federation

RSBIH "Smolensk Regional Clinical Hospital"; 🇷🇺 Smolensk, Russian Federation

Clinical Center Kragujevac; 🇷🇸 Kragujevac, Serbia

Clinical Center Nis; 🇷🇸 NIS, Serbia

MUDr. Beata Dupejova Neurologicka ambulancia s.r.o; 🇸🇰 Banska Bystrica, Slovakia

Univerzitna nemocnica Bratislava Nemocnica Ruzinov; 🇸🇰 Bratislava, Slovakia

Fakultna nemocnica s poliklinikou Zilina; 🇸🇰 Žilina, Slovakia

Hospital Universitari de Bellvitge; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Santa Caterina; 🇪🇸 Salt, Girona, Spain

Complejo Hospitalario Universitario de Santiago (CHUS) Servicio de Neurologia; 🇪🇸 Santiago de Compostela, LA Coruna, Spain

Walton Centre For Neurology and Neurosurgery; 🇬🇧 Liverpool, United Kingdom

Hospital Universitario Puerta de Hierro - Majadahonda; 🇪🇸 Majadahonda, Madrid, Spain

Hospital de Basurto; 🇪🇸 Bilbao, Vizcaya, Spain

Hospital Vall d'Hebron; 🇪🇸 Barcelona, Spain

Hospital Universitario de la Princesa; 🇪🇸 Madrid, Spain

Hospital Universitario Ramon y Cajal; 🇪🇸 Madrid, Spain

Hospital Universitario Clínico San Carlos; 🇪🇸 Madrid, Spain

Hospital Regional Universitario de Malaga; 🇪🇸 Malaga, Spain

Hospital Universitario Virgen Macarena; 🇪🇸 Sevilla, Spain

Sahlgrenska Sjukhuset; 🇸🇪 Göteborg, Sweden

Akademiskt Specialist Centrum; 🇸🇪 Stockholm, Sweden

Universitaetsspital Basel; 🇨🇭 Basel, Switzerland

Ospedale Regionale di Lugano; 🇨🇭 Lugano, Switzerland

Hopital Razi; 🇹🇳 Mannouba, Tunisia

Hopital Universitaire Fattouma Bourguiba; 🇹🇳 Monastir, Tunisia

Istanbul University Cerrahpasa Medical Faculty; 🇹🇷 Istanbul, Turkey

Ondokuz Mayis Univ. Med. Fac.; 🇹🇷 Samsun, Turkey

Karadeniz Tecnical Uni. Med. Fac; 🇹🇷 Trabzon, Turkey

Medical Center of Limited Liability Company Medical Center Saliutem; 🇺🇦 Vinnytsia, Chernihiv Governorate, Ukraine

Separated structural unit ?University hospital? of Dnipro State Medical University; 🇺🇦 Dnipro, Dnipropetrovs'ka Oblast, Ukraine

Institute of Neurology Psychiatry and Narcology of NAMS of Ukraine; 🇺🇦 Kharkiv, Kharkiv Governorate, Ukraine

Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital; 🇺🇦 Lviv, Kharkiv Governorate, Ukraine

CMPI Chernihiv Regional Hospital; 🇺🇦 Chernihiv, KIEV Governorate, Ukraine

CNE Regional Clinical Hospital of Ivano-Frankivsk Regional Council; 🇺🇦 Ivano Frankivsk, KIEV Governorate, Ukraine

Medical Center of Limited Liability Company Medbud-Clinic; 🇺🇦 Kyiv, KIEV Governorate, Ukraine

CNE of Lviv Reg Clin Hospital Dept of Neurology D.Halytskyi Lviv NMU; 🇺🇦 Lviv, KIEV Governorate, Ukraine

CNE Odesa Regional Clinical Hospital of Odesa Regional Council; 🇺🇦 Odesa, KIEV Governorate, Ukraine

Nottingham University Hospitals Queen's Medical Centre; 🇬🇧 Nottingham, Nottinghamshire, United Kingdom

Royal Devon and Exeter Hospital (Wonford); 🇬🇧 Exeter, United Kingdom

Barts Health NHS Trust; 🇬🇧 London, United Kingdom

Royal Victoria Infirmary; 🇬🇧 Newcastle, United Kingdom

Morriston Hospital; 🇬🇧 Swansea, United Kingdom