Molecular detection of the bacterial load as a diagnostic and monitoring tool for optimal antibiotic treatment in endocarditis
Completed
- Conditions
- cardiac valve infectionendocarditis1004697310004018
- Registration Number
- NL-OMON35768
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
- Adult patients (*18 years) with suspected endocarditis, admitted in one of the participating hospitals
- Written informed consent is obtained
Exclusion Criteria
- Failure to obtain written informed consent to participate
- Endocarditis caused by Coxiella burnettii (Q-fever)
- An Hb below 5.0 mmol/L
- Death before first sample is obtained
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Determination of the diagnostic value of mBL for the diagnosis of bacterial<br /><br>endocarditis with endocarditis defined according to Duke criteria<br /><br>- Prognostic value of mBL in patients with endocarditis according to Duke<br /><br>criteria with regard to the occurrence of a complicated course<br /><br>- A descriptive model of the kinetics of mBL related to infectious parameters<br /><br>(CRP, WBC, PCT) in patients with an uncomplicated treatment course of bacterial<br /><br>endocarditis.<br /><br><br /><br><br /><br>.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Determination of the diagnostic value of mBL for the diagnosis of bacterial<br /><br>endocarditis compared to blood culture results and laboratory markers (e.g.<br /><br>CRP, procalcitonin, WBC).<br /><br>- Prognostic value of mBL in patients with endocarditis according to Duke<br /><br>criteria with regard to other outcome parameters (mortality, surgery)<br /><br>- Correlation of mBL at start of therapy with clinical severity scores (PITT<br /><br>bacteremia score, APACHE II score).<br /><br>- Correlation of mBL at start of therapy with the occurrence of a complicated<br /><br>treatment course at a later time point.<br /><br>- Daignostic and prognostic value of 'host response markers' in patients with<br /><br>bacterial endocarditis.</p><br>