ISRCTN15635197已完成未知
Protocolised trial of invasive and non-invasive weaning off ventilation (The 'Breathe' Study): a pragmatic randomised controlled open multi-centre effectiveness trial
Heart of England NHS Foundation Trust (UK)0 个研究点目标入组 364 人开始时间: 2012年11月29日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 364
研究概览
简要总结
- 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30347090 2. 2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31532358 (added 19/09/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Male and female, age > 16 years
- •2. Patients with respiratory failure who have received invasive ventilation for more than 48 hours (from the time of intubation)
- •3. Fail a spontaneous breathing trial (SBT)
- •4. Provision of written informed consent
- •The trial inclusion criteria will be adult patients with respiratory failure who have received invasive ventilation for more than 48 hours (from the time of intubation) and fail a SBT. We will not include patients who require shorter periods of invasive ventilation or those who pass the SBT as this group are typically rapidly weaned and have good clinical outcomes.
排除标准
- •1. Presence of tracheostomy
- •2. Profound neurological deficit
- •3. Any absolute contraindication to NIV
- •4. Home ventilation prior to ICU admission
- •5. Decision not to re-intubate or withdrawal of care anticipated
- •6. Further surgery / procedure requiring sedation planned in next 48 hours
- •7. Previous participation in the trial
研究者
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