NCT05920902招募中不适用
Arterial Spin Label Depicted Ischemic Stroke Cohort (ASLIS)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Progressively deterioration in acute phase
研究概览
简要总结
Establish a clinical cohort of acute ischemic stroke patients and find the determinant of the prognosis.
详细描述
- Enrollment: screening the candidates based on the inclusion and exclusion criteria, and sign the informed consent.
- Baseline evaluation: evaluate baseline situation of enrolled candidates.
- Inpatient view: view and evaluate enrolled candidates respectively at day 1, 3, 7 and 14 after stroke, and record the results.
- Follow-up: view the candidates at 90 days and one year after stroke onset, and record the results.
- Data analysis: analyze the results.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 30-90, no gender restrictions.
- •Onset of disease ≤7 days.
- •Meet either of the following two conditions:
- •① Transient ischemic attack (TIA)
- •② Ischemia stroke (IS) Note: Acute IS diagnosis criteria: sudden and persistent focal or widespread neurological dysfunction, excluding other non-vascular causes of brain dysfunction (such as brain infection, head injury, brain tumor, epilepsy, severe metabolic diseases, or degenerative neurological diseases), confirmed by image as new IS. TIA diagnosis criteria: sudden and reversible focal neurological or retinal ischemic deficit caused by a reversible ischemia, usually lasting less than 24 hours, with no evidence of new IS on imaging, and excluding other non-ischemic causes (such as brain infection, head injury, brain tumor, epilepsy, severe metabolic diseases, or degenerative neurological diseases).
- •Signed informed consent
排除标准
- •Clear cause of ischemic stroke other than atrial fibrillation.
- •Other ischemic strokes with a clear cause.
- •Presence of non-vascular intracranial disease.
- •Presence of severe systemic diseases.
- •Pregnancy or lactation.
- •Unable to tolerate or cooperate with MRI examination.
- •Unable to comply with follow-up due to geographical or other reasons.
结局指标
主要结局
Progressively deterioration in acute phase
时间窗: 7 days after ischemia stroke onset
Number of participants whose SNOB (Standardised nursing observations for stroke) score at 7 days post ischemia stroke ≤ 2 points compared to baseline, and/or NIHSS score at 7 days post ischemia stroke ≥ 2 points compared to baseline are identified as progressively deterioration in acute phase.
Bad prognosis of acute ischemia stroke
时间窗: 90 days after ischemia stroke onset
Number of participants whose mRS (Modified rankin scale) score at 90 days after ischemia \> 2 are identified as bad prognosis.
次要结局
- Recurrent vascular episode(1 year)
- Recurrent artery stenosis(one year after stenting)
- Unhealthy status(1 year)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
Unknown
Development and validation of automatic diagnostic system for stroke in acute dizzinessDiseases of the nervous systemKCT0008366Pusan National University200
招募中
不适用
Prospective Cohort With Incident StrokeIschemic StrokeNCT01364168Ludwig-Maximilians - University of Munich850
Unknown
不适用
Endovascular Treatment in Ischemic Stroke Follow-up EvaluationStroke, AcuteNCT03776877Hopital Foch4,000
已完成
不适用
Biomarkers algOrithm for strOke diagnoSis and Treatment Resistance PredictionStroke, IschemicLarge Vessel OcclusionNCT04726839Assistance Publique - Hôpitaux de Paris3,880
已完成
不适用
Stroke and Traumatic Acute Brain Injury Line Indicator System for Emergent Recognition (STABILISER-I)Ischemic StrokeHemorrhagic StrokeTraumatic Brain InjuryNCT02514902Justin Fraser48