Effects of expectations on pain perception and learning in fibromyalgia patients

Completed

Conditions: pijnstoornissen
fibromyalgia

Registration Number: NL-OMON45539

Lead Sponsor: niversiteit Leiden

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Female
- 18-65 years old
- Able to give written informed consent;Additional inclusion criterion for patient group:
- Diagnosed with fibromyalgia by a rheumatologist, according to the ACR criteria (1990 or 2010)

Exclusion Criteria

At least one of the following criteria for all subjects:
- Significant intellectual or learning disabilities
- Visual or hearing disabilities (contacts or glasses are ok)
- Obesity (body mass index > 30 kg/m2)
- Medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease
- History of chronic alcohol or illicit drug use
- Regular use of opioids (tramadol, oxycodone, morphine, fentanyl, etc)
- Pregnancy
- Use of painkillers or other *rescue* (irregular) medication < 48 hours before the experiment
- History of epilepsy
- Abnormal amount of current pain (e.g., due to recent injury or surgery)
- Any other condition that, as judged by the investigator, is expected to interfere with optimal study participation, or could confound the results of the study ;Additional exclusion criterion for patient group:
- Presence of any other pain syndrome, other than fibromyalgia (such as osteoarthritis, polyneuropathy, rheumatic disease, etc)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pain-learning task:<br /><br>- Cue effect on reported pain during the extinction phase<br /><br>- Cue effect on heat-evoked skin-conductance responses during the extinction<br /><br>phase<br /><br>- Confirmation bias on learning rate during the extinction phase<br /><br>Visual-discrimination task:<br /><br>- Reported unpleasantness and discrimination accuracy of visual stimulation, as<br /><br>a function of stimulation intensity</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Learning rate on the reward-learning task (to assess the specificity of<br /><br>potential learning abnormalities in the patient group to aversive learning<br /><br>situations)<br /><br>- Temporal summation phenomenon<br /><br>- Overall sensitivity to heat pain (self-reported pain and skin-conductance<br /><br>responses to contact heat)<br /><br>- Questionnaire scores (see section 5.2)</p><br>