Effect of dexamethasone,ketamine,magnesium sulphate nebulization on attenuation of sore throat,hoarseness of voice and cough in general anaesthesia

Not yet recruiting

• Conditions: Edema of larynx,

• Registration Number: CTRI/2023/06/053612
• Lead Sponsor: FORTIS HOSPITAL, MOHALI

Brief Summary

Post operative sore throat (POST) is one of the most common complication in general anaesthesia along with hoarseness of voice and cough. These all maybe considered as a minor complication after surgery and anaesthesia that resolve after few days but it causes discomfort to the patient and decreases the quality of recovery and patient satisfaction. Although symptoms subside without any treatment, the management for POST is still advised. Various pharmacological agents have been used to prevent POST including both intravenous, topical and nebulized drugs. Intravenous agents include steroids, ketamine, magnesium sulphate and lignocaine. Drugs like magnesium sulphate, ketamine, dexamethasone, lignocaine have been used as gargles, topical application on endotracheal tube or nebulization with varying efficacies.

Nebulization is considered better than gargles as it is an easier way to administer the drug, requires a small volume of drug, pungent taste of gargled medication is avoided and is safer method of drug delivery.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-05-06
• Study Start: 2023-06-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• Patients between 18 to 65 years of either sex undergoing surgery in general anaesthesia in supine position.
• Duration of surgery upto 2 hours.
• ASA Grade I and II.

Exclusion Criteria

• ASA Grade III and IV.
• History of recent upper airway infection.
• Anticipated difficult airway.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the incidence and severity of post operative sore throat.	0, 1, 4 and 24 hours.

Secondary Outcome Measures

Name	Time	Method
To assess the incidence and severity of post operative hoarseness of voice and cough, hemodynamic parameters and side effects if any.	0, 1, 4 and 24 hours.

Trial Locations

Locations (1)

FORTIS HOSPITAL, MOHALI; 🇮🇳 Sahib, PUNJAB, India

FORTIS HOSPITAL, MOHALI

🇮🇳Sahib, PUNJAB, India

DR JASMEET KAUR

Principal investigator

9781995392

jasmeetkaurdr@gmail.com