ACTRN12621000606886招募中未知
PharmacoKinetic modelling for Antimicrobials in Paediatric Patients on Extracorporeal Therapies (APET)
Queesland Children's Hospital0 个研究点目标入组 140 人开始时间: 2021年5月20日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- o limit 至 18 Years（—）
- 性别
- All
入选标准
- •Patient will be recruited if they meet the inclusion criteria.
- •INCLUSION CRITERIA
- •Paediatrics from birth up to 18 years of age admitted to Paediatric Intensive Care Unit at the Queensland Children’s Hospital and the University Children's Hospital Zurich are eligible if ALL of the following criteria are met.
- •1. Consent to continue approach (consent will be sought with a followup of written or phone consent to be obtained from the parent or carer, within 24 hours of inclusion in the study.
- •2. Paediatric patients requiring extracorporeal therapies either extracorporeal membrane oxygenation and/or continuous renal replacement therapy.
- •3. Patients are prescribed one or more of the following antimicrobials: cefotaxime, meropenem, ampicillin, piperacillin/tazobactam, vancomycin, gentamicin, flucloxacillin, fluconazole, voriconazole, fluconazole, micafungin, anidulafungin, ceftazidime and teicoplanin.
- •4. Patients may receive multiple antimicrobials concurrently.
- •5. indwelling catheter
排除标准
- •Patient will not be included if they meet the exclusion criteria
- •EXCLUSION CRITERIA
- •Patients are excluded from the study if ONE OR MORE of the following criteria are met:
- •1. No consent to continue
- •2. Known allergy to study antimicrobial
- •3. Pregnancy
- •4. Ongoing massive blood transfusion requirements (>50% blood volume transfused in the previous 8 hours) 5. Haemoglobin is less than 70 g/L
- •6. Therapeutic plasma exchange in the preceding 24 hours
- •7. No arterial or venous access for sampling
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