ACTRN12612000559819招募中未知
Pharmacokinetic modelling of antibiotic, sedative and analgesic drugs and their relevant metabolites in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and development of dosing guidelines to optimise drug therapy during ECMO.
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 160
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 89 Years（—）
- 性别
- All
入选标准
- •Currently undergoing ECMO for respiratory +/- cardiac dysfunction
- •- Clinical indication for the antibiotics ceftriaxone, cefepime, meropenem, gentamicin, ciprofloxacin, ticarcillin-clavulanate, piperacillin-tazobactum, vancomycin, linezolid, caspofungin, fluconazole, voriconazole and oseltamivir
- •- Clinical indication for the sedatives and analgesics morphine, fentanyl, midazolam, dexmedetomidine, propfol or thiopentone
排除标准
- •- No valid consent
- •- Known allergy to study drug
- •- Pregnancy
- •- S. Bilirubin >150
- •- Ongoing massive blood loss and blood product transfusion
- •- Therapeutic plasma exchange in the last 24 hours.
研究者
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