The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Changes in uterine artery resistance index
研究概览
简要总结
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes
详细描述
100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Singleton pregnancy.
- •Primigravida or Multigravida.
- •Pregnant females ≥ 37 weeks of gestation.
- •Diagnosed as severe preeclampsia by the following criteria:
- •Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg.
- •Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams.
- •Oliguria or creatinine > 1.1 mg%.
- •Laboratory findings characteristic of HELLP syndrome.
- •Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain.
排除标准
- •Multifetal pregnancy.
- •History of epilepsy.
- •Patients with diabetes.
- •Patients with renal disease.
- •Fetuses with congenital anomalies.
- •Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight).
- •Patients with severe IUGR.
- •Patients with accidental hemorrhage.
研究组 & 干预措施
MgSO4
The magnesium sulfate will be given according to the regimen of 6 grams intravenous over 20 minutes as a loading dose.
干预措施: MgSO4 (Drug)
结局指标
主要结局
Changes in uterine artery resistance index
时间窗: 15 minutes after the loading dose of MgSO4
Doppler assessment of uterine artey RI
次要结局
未报告次要终点
研究者
Ahmed M Maged, MD
Principal investigator
Cairo University